⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL256090 | 0.78 | — | — | |
| SCHEMBL10962816 | 0.77 | L3MBTL1 (0.34) | — | |
| SCHEMBL9435912 | 0.76 | — | — | |
| SCHEMBL1005836 | 0.76 | — | — | |
| SCHEMBL1509606 | 0.76 | — | — | |
| SCHEMBL12844533 | 0.76 | — | — | |
| SCHEMBL7999506 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL7447885 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL1636691 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL9435572 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9402914-B2 | Membrane lytic poly(amido amine) polymers for the delivery of oligonucleotides | SIRNA THERAPEUTICS, INC. (US) | 2016-08-02 | — | — | US | claimed |
| US-9402914-B2 | Membrane lytic poly(amido amine) polymers for the delivery of oligonucleotides | SIRNA THERAPEUTICS, INC. (US) | 2016-08-02 | — | — | US | disclosed |
| US-20150165058-A1 | MEMBRANE LYTIC POLY(AMIDO AMINE) POLYMERS FOR THE DELIVERY OF OLIGONUCLEOTIDES | BANK OF AMERICA, N.A. | 2015-06-18 | — | — | US | disclosed |
| US-8901101-B2 | Membrane lytic poly(amido amine) polymers for the delivery of oligonucleotides | SIRNA THERAPEUTICS, INC. (US) | 2014-12-02 | — | — | US | disclosed |
| US-20130289207-A1 | MEMBRANE LYTIC POLY(AMIDO AMINE) POLYMERS FOR THE DELIVERY OF OLIGONUCLEOTIDES | BANK OF AMERICA, N.A. | 2013-10-31 | — | — | US | disclosed |
| WO-2012082574-A1 | MEMBRANE LYTIC POLY(AMIDO AMINE) POLYMERS FOR THE DELIVERY OF OLIGONUCLEOTIDES | MERCK SHARP & DOHME CORP. (US) | 2012-06-21 | — | — | WO | disclosed |