Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7999506 | 0.98 | — | — | |
| Hydrochloric Acid SCHEMBL9435572 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL1636691 | 0.77 | — | — | |
| SCHEMBL256090 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL6604615 | 0.74 | TDP1 (0.36) | — | |
| SCHEMBL9435912 | 0.74 | — | — | |
| SCHEMBL1509606 | 0.74 | — | — | |
| SCHEMBL1005836 | 0.74 | — | — | |
| SCHEMBL12844533 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL2937447 | 0.72 | AGXT (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0003052-B1 | PROCESS FOR THE PREPARATION OF 4-METHYL-5-CHLOROMETHYL-IMIDAZOLE | BASF Aktiengesellschaft (DE) | 1981-03-18 | — | — | EP | claimed |
| US-4211875-A | Preparation of 4-methyl-5-chloromethyl-imidazole | BASF AKTIENGESELLSCHAFT (DE) | 1980-07-08 | — | — | US | claimed |
| EP-0003052-A2 | Process for the preparation of 4-methyl-5-chloromethyl-imidazole | BASF Aktiengesellschaft (DE) | 1979-07-25 | — | — | EP | claimed |
| EP-0397365-B1 | Arylthiazolylimidazoles as 5HT3 Antagonists | PFIZER (US) | 1994-03-02 | — | — | EP | disclosed |
| US-4973703-A | ACTIVATED CARBON IN WATER IN PRESENCE OR ORGANIC ACID | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1990-11-27 | — | — | US | disclosed |
| EP-0397365-A1 | Arylthiazolylimidazoles as 5HT3 Antagonists | PFIZER INC. (US) | 1990-11-14 | — | — | EP | disclosed |
| US-4914207-A | ANTIEMETICS | PFIZER INC. (US) | 1990-04-03 | — | — | US | disclosed |
| US-4847383-A | IMIDAZOLE BLOCKING AGENTS WHICH CLEAVE TO RELEASE TETRAZOLE | POLAROID CORPORATION (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0317131-A1 | Process for purification of N-cyano-N'-methyl-N''-[2-((5-methyl-1H-imidazol-4-yl)methylthio)ethyl]guanidine | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1989-05-24 | — | — | EP | disclosed |
| EP-0145037-B1 | N-(BICYCLIC HETEROCYCLYL)-4-PIPERIDINAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-01-18 | — | — | EP | disclosed |
| EP-0129033-B1 | PHOTOGRAPHIC PRODUCTS AND NOVEL COMPOUNDS | POLAROID CORPORATION (US) | 1988-07-27 | — | — | EP | disclosed |
| US-4211875-A | Preparation of 4-methyl-5-chloromethyl-imidazole | BASF AKTIENGESELLSCHAFT (DE) | 1980-07-08 | — | — | US | disclosed |
| US-4200760-A | ANTIULCER, H2-RECEPTOR BLOCKING AGENTS | BRISTOL-MYERS COMPANY (US) | 1980-04-29 | — | — | US | disclosed |
| US-4189592-A | Preparation of 4-methyl-5-[(2-aminoethyl)-thiomethyl]-imidazole dihydrochloride | BASF AKTIENGESELLSCHAFT (DE) | 1980-02-19 | — | — | US | disclosed |
| US-4173644-A | HISTAMINE ANTAGONISTS, ANTIINFLAMMATORY AGENTS, ANTISECRETORY AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-11-06 | — | — | US | disclosed |
| EP-0004535-A2 | Process for preparing 4-methyl-5-((2-aminoethyl)-thiomethyl)-imidazole-dihydro chloride | BASF Aktiengesellschaft (DE) | 1979-10-17 | — | — | EP | disclosed |
| EP-0003052-A2 | Process for the preparation of 4-methyl-5-chloromethyl-imidazole | BASF Aktiengesellschaft (DE) | 1979-07-25 | — | — | EP | disclosed |
| US-4158013-A | N-Cyano-N'-alkynyl-N\"-2-mercaptoethylguanidines | BRISTOL-MYERS COMPANY (US) | 1979-06-12 | — | — | US | disclosed |
| US-4120966-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-10-17 | — | — | US | disclosed |
| US-4120972-A | HISTAMINE HYDROGEN-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-10-17 | — | — | US | disclosed |