Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPB2 | Q96IY4 | 5/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.43 |
| ▸ | CPB1 | P15086 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 6/20 | 0.39 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | HTT | P42858 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | GALR3 | O60755 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9939293 | 1.00 | CPB2 (0.46) | CPB2TBXAS1CPB1NPC1RAB9A | |
| SCHEMBL9941648 | 1.00 | CPB2 (0.46) | CPB2TBXAS1CPB1NPC1RAB9A | |
| SCHEMBL9941754 | 0.93 | CPB2 (0.47) | CPB2TBXAS1CPB1LMNAPOLB | |
| SCHEMBL8795862 | 0.87 | CPB2 (0.44) | CPB2TBXAS1CPB1NPC1RAB9A | |
| SCHEMBL28878999 | 0.84 | CPB2 (0.47) | CPB2TBXAS1CPB1NPC1RAB9A | |
| SCHEMBL4373193 | 0.81 | CPB2 (0.46) | CPB2TBXAS1CPB1NPC1RAB9A | |
| SCHEMBL9570115 | 0.80 | CPB2 (0.47) | CPB2TBXAS1CPB1NPC1RAB9A | |
| SCHEMBL9597175 | 0.80 | CPB2 (0.47) | CPB2TBXAS1CPB1NPC1RAB9A | |
| SCHEMBL8934793 | 0.79 | CPB2 (0.45) | CPB2TBXAS1CPB1LMNAPOLB | |
| Bromide SCHEMBL16738793 | 0.79 | CPB2 (0.45) | CPB2TBXAS1CPB1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9402914-B2 | Membrane lytic poly(amido amine) polymers for the delivery of oligonucleotides | SIRNA THERAPEUTICS, INC. (US) | 2016-08-02 | — | — | US | claimed |
| US-9402914-B2 | Membrane lytic poly(amido amine) polymers for the delivery of oligonucleotides | SIRNA THERAPEUTICS, INC. (US) | 2016-08-02 | — | — | US | disclosed |
| US-20150165058-A1 | MEMBRANE LYTIC POLY(AMIDO AMINE) POLYMERS FOR THE DELIVERY OF OLIGONUCLEOTIDES | BANK OF AMERICA, N.A. | 2015-06-18 | — | — | US | disclosed |
| US-8901101-B2 | Membrane lytic poly(amido amine) polymers for the delivery of oligonucleotides | SIRNA THERAPEUTICS, INC. (US) | 2014-12-02 | — | — | US | disclosed |
| US-20130289207-A1 | MEMBRANE LYTIC POLY(AMIDO AMINE) POLYMERS FOR THE DELIVERY OF OLIGONUCLEOTIDES | BANK OF AMERICA, N.A. | 2013-10-31 | — | — | US | disclosed |
| WO-2012082574-A1 | MEMBRANE LYTIC POLY(AMIDO AMINE) POLYMERS FOR THE DELIVERY OF OLIGONUCLEOTIDES | MERCK SHARP & DOHME CORP. (US) | 2012-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150165058-A1 | MEMBRANE LYTIC POLY(AMIDO AMINE) POLYMERS FOR THE DELIVERY OF OLIGONUCLEOTIDES | PUF60, PHOSPHO1, PARG | CPB2 1157/4885TBXAS1 4152/4885CPB1 705/4885 |
| US-20130289207-A1 | MEMBRANE LYTIC POLY(AMIDO AMINE) POLYMERS FOR THE DELIVERY OF OLIGONUCLEOTIDES | PUF60, PHOSPHO1, PARG | CPB2 1157/4885TBXAS1 4152/4885CPB1 705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.