Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | MAOB | P27338 | 7/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MAOA | P21397 | 2/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA3 | P07451 | 1/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.54 |
| ▸ | CA6 | P23280 | 1/20 | 0.54 |
| ▸ | CA7 | P43166 | 1/20 | 0.54 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5162745 | 0.87 | MAOB (0.68) | ALOX5MAOBMEN1KMT2AMAOA | |
| SCHEMBL8984340 | 0.86 | ALOX5 (0.92) | ALOX5CYP3A4MAOBNPC1RAB9A | |
| SCHEMBL51460 | 0.86 | ALOX5 (1.00) | ALOX5CYP3A4MAOBNPC1RAB9A | |
| SCHEMBL7402902 | 0.86 | ALOX5 (0.71) | ALOX5CYP3A4MAOBNPC1RAB9A | |
| SCHEMBL3239909 | 0.86 | ALOX5 (0.71) | ALOX5CYP3A4MAOBNPC1RAB9A | |
| SCHEMBL28662350 | 0.85 | ALOX5 (0.89) | ALOX5CYP3A4MAOBNPC1RAB9A | |
| SCHEMBL2636350 | 0.84 | ALOX5 (0.73) | ALOX5CYP3A4MAOBNPC1RAB9A | |
| SCHEMBL29576561 | 0.84 | ALOX5 (0.73) | ALOX5CYP3A4MAOBNPC1RAB9A | |
| SCHEMBL27613728 | 0.83 | ALOX5 (0.67) | ALOX5CYP3A4MAOBNPC1RAB9A | |
| SCHEMBL5571034 | 0.82 | AGXT (0.63) | ALOX5NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651871-A1 | NOVEL SUBSTITUTED BICYCLIC AROMATIC COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS | N30 Pharmaceuticals, Inc. (US) | 2013-10-23 | — | — | EP | disclosed |
| WO-2012170371-A1 | COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS | N30 PHARMACEUTICALS, LLC (US) | 2012-12-13 | — | — | WO | disclosed |
| WO-2012083171-A1 | NOVEL SUBSTITUTED BICYCLIC AROMATIC COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS | N30 PHARMACEUTICALS, LLC (US) | 2012-06-21 | — | — | WO | disclosed |