⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10251778 | 0.86 | — | — | |
| SCHEMBL5838803 | 0.67 | THRB (0.33) | — | |
| SCHEMBL22470613 | 0.67 | THRB (0.33) | — | |
| SCHEMBL9939735 | 0.67 | — | — | |
| SCHEMBL787220 | 0.65 | THRB (0.43) | — | |
| SCHEMBL22470611 | 0.65 | THRB (0.43) | — | |
| SCHEMBL194318 | 0.65 | THRB (0.43) | — | |
| SCHEMBL644282 | 0.64 | — | — | |
| SCHEMBL21776612 | 0.63 | — | — | |
| SCHEMBL2251688 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11814338-B2 | Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators | REATA PHARMACEUTICALS, INC. (US) | 2023-11-14 | — | — | US | disclosed |
| US-20230060178-A1 | ORGANOBORANE STRATEGY FOR POLYMERS BEARING LACTONE, ESTER, AND ALCOHOL FUNCTIONALITY | NATIONAL SCIENCE FOUNDATION | 2023-03-02 | — | — | US | disclosed |
| US-11591314-B2 | Process for preparing tetrahydrocarbazole carboxamide compound | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-02-28 | — | — | US | disclosed |
| US-20220281807-A1 | PYRAZOLYL AND PYRIMIDINYL TRICYCLIC ENONES AS ANTIOXIDANT INFLAMMATION MODULATORS | REATA PHARMACEUTICALS, INC. (US) | 2022-09-08 | — | — | US | disclosed |
| US-11192852-B2 | Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators | REATA PHARMACEUTICALS, INC. (US) | 2021-12-07 | — | — | US | disclosed |
| WO-2021113344-A1 | ORGANOBORANE STRATEGY FOR POLYMERS BEARING LACTONE, ESTER, AND ALCOHOL FUNCTIONALITY | THE JOHNS HOPKINS UNIVERSITY (US) | 2021-06-10 | — | — | WO | disclosed |
| US-20210078980-A1 | PROCESS FOR PREPARING TETRAHYDROCARBAZOLE CARBOXAMIDE COMPOUND | BRISTOL MYERS SQUIBB CO (US) | 2021-03-18 | — | — | US | disclosed |
| US-10875843-B2 | Process for preparing tetrahydrocarbazole carboxamide compound | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-12-29 | — | — | US | disclosed |
| EP-3558977-B1 | PROCESS FOR PREPARING TETRAHYDROCARBAZOLE CARBOXAMIDE COMPOUND | BRISTOL MYERS SQUIBB CO (US) | 2020-10-28 | — | — | EP | disclosed |
| US-20200207706-A1 | PYRAZOLYL AND PYRIMIDINYL TRICYCLIC ENONES AS ANTIOXIDANT INFLAMMATION MODULATORS | REATA PHARMACEUTICALS, INC. (US) | 2020-07-02 | — | — | US | disclosed |
| WO-2018118830-A1 | PROCESS FOR PREPARING TETRAHYDROCARBAZOLE CARBOXAMIDE COMPOUND | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-06-28 | — | — | WO | disclosed |
| US-9884809-B2 | Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators | REATA PHARMACEUTICALS, INC. (US) | 2018-02-06 | — | — | US | disclosed |
| EP-2651902-B1 | PYRAZOLYL AND PYRIMIDINYL TRICYCLIC ENONES AS ANTIOXIDANT INFLAMMATION MODULATORS | REATA PHARMACEUTICALS INC (US) | 2017-11-08 | — | — | EP | disclosed |
| US-20160130220-A1 | PYRAZOLYL AND PYRIMIDINYL TRICYCLIC ENONES AS ANTIOXIDANT INFLAMMATION MODULATORS | REATA PHARMACEUTICALS, INC. (US) | 2016-05-12 | — | — | US | disclosed |
| US-9174941-B2 | Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators | REATA PHARMACEUTICALS, INC. (US) | 2015-11-03 | — | — | US | disclosed |
| US-20140051739-A1 | PYRAZOLYL AND PYRIMIDINYL TRICYCLIC ENONES AS ANTIOXIDANT INFLAMMATION MODULATORS | REATA PHARMACEUTICALS, INC. | 2014-02-20 | — | — | US | disclosed |
| EP-2651902-A2 | PYRAZOLYL AND PYRIMIDINYL TRICYCLIC ENONES AS ANTIOXIDANT INFLAMMATION MODULATORS | Reata Pharmaceuticals, Inc. (US) | 2013-10-23 | — | — | EP | disclosed |
| US-8513436-B2 | Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators | REATA PHARMACEUTICALS, INC. (US) | 2013-08-20 | — | — | US | disclosed |
| US-20120196880-A1 | PYRAZOLYL AND PYRIMIDINYL TRICYCLIC ENONES AS ANTIOXIDANT INFLAMMATION MODULATORS | REATA PHARMACEUTICALS, INC. | 2012-08-02 | — | — | US | disclosed |
| WO-2012083306-A2 | PYRAZOLYL AND PYRIMIDINYL TRICYCLIC ENONES AS ANTIOXIDANT INFLAMMATION MODULATORS | REATA PHARMACEUTICALS, INC. (US) | 2012-06-21 | — | — | WO | disclosed |