Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.34 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.34 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.34 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.31 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9900059 | 0.91 | MAPT (0.54) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL9899616 | 0.86 | OPRK1 (0.39) | MAPTALDH1A1OPRK1NR1I2SMARCA2 | |
| SCHEMBL15033832 | 0.83 | OPRK1 (0.37) | ALDH1A1OPRK1NR1I2SMARCA2SMARCA4 | |
| SCHEMBL9939953 | 0.77 | MAPT (0.44) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL9899723 | 0.75 | MAPT (0.57) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL9899670 | 0.75 | MAPT (0.54) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL9899672 | 0.75 | MAPT (0.54) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL9899970 | 0.70 | MAPT (0.56) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL9899367 | 0.69 | NR1I2 (0.38) | NR1I2SMARCA2SMARCA4PBRM1NR1H2 | |
| SCHEMBL9899369 | 0.69 | NR1I2 (0.38) | NR1I2SMARCA2SMARCA4PBRM1NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012076672-A1 | 2 -AMINOBENZ IMIDAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF INFLAMMATION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-14 | — | — | WO | disclosed |