Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 9/20 | 0.48 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | USP1 | O94782 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15282735 | 0.91 | DGAT1 (0.60) | DGAT1S1PR2PTGS1PTGS2METAP2 | |
| SCHEMBL20169338 | 0.85 | DGAT1 (0.44) | DGAT1PTGS1PTGS2METAP2 | |
| SCHEMBL15293918 | 0.78 | DGAT1 (0.72) | DGAT1 | |
| SCHEMBL18085602 | 0.74 | DGAT1 (0.69) | DGAT1PTGS1PTGS2 | |
| SCHEMBL16787746 | 0.73 | DGAT1 (0.78) | DGAT1PTGS1PTGS2USP1 | |
| SCHEMBL15293832 | 0.70 | DGAT1 (0.64) | DGAT1PTGS1PTGS2 | |
| SCHEMBL20169353 | 0.69 | DGAT1 (0.52) | DGAT1PTGS1PTGS2 | |
| SCHEMBL9940375 | 0.69 | DGAT1 (0.61) | DGAT1PTGS1PTGS2 | |
| SCHEMBL25230088 | 0.68 | DGAT1 (0.57) | DGAT1USP1 | |
| SCHEMBL9936872 | 0.68 | DGAT1 (0.63) | DGAT1PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651915-A1 | CONTINUOUS ARYCYCLIC COMPOUND | Mitsubishi Tanabe Pharma Corporation (JP) | 2013-10-23 | — | — | EP | disclosed |
| WO-2012081736-A1 | CONTINUOUS ARYCYCLIC COMPOUND | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-06-21 | — | — | WO | disclosed |