Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 10/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
| ▸ | HTR3B | O95264 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.42 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9940613 | 0.93 | CYP3A4 (0.49) | CYP3A4OPRL1CYP2D6HTR3EHTR3B | |
| SCHEMBL9974828 | 0.89 | CYP3A4 (0.45) | CYP3A4OPRL1CYP2D6HTR3EHTR3B | |
| SCHEMBL9940537 | 0.87 | CYP3A4 (0.44) | CYP3A4OPRL1CYP2D6HTR3EHTR3B | |
| SCHEMBL9940755 | 0.82 | CYP3A4 (0.41) | CYP3A4OPRL1CYP2D6HTR3EHTR3B | |
| SCHEMBL16696088 | 0.81 | CYP3A4 (0.59) | CYP3A4OPRL1CYP2D6HTR3EHTR3B | |
| SCHEMBL9940550 | 0.77 | CYP3A4 (0.51) | CYP3A4OPRL1CYP2D6TNKSOPRM1 | |
| SCHEMBL9974836 | 0.76 | CYP3A4 (0.46) | CYP3A4CYP2D6TNKS | |
| SCHEMBL16696058 | 0.76 | CYP3A4 (0.53) | CYP3A4OPRL1CYP2D6HTR3EHTR3B | |
| SCHEMBL9940754 | 0.75 | HTR3A (0.41) | CYP3A4OPRL1CYP2D6HTR3EHTR3B | |
| SCHEMBL16696071 | 0.75 | CYP3A4 (0.56) | CYP3A4OPRL1CYP2D6TNKSOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9944638-B2 | Indoles as respiratory syncytial virus antiviral agents | JANSSEN SCIENCES IRELAND US (IE) | 2018-04-17 | — | — | US | disclosed |
| US-9944638-B2 | Indoles as respiratory syncytial virus antiviral agents | JANSSEN SCIENCES IRELAND US (IE) | 2018-04-17 | — | — | US | disclosed |
| US-9944638-B2 | Indoles as respiratory syncytial virus antiviral agents | JANSSEN SCIENCES IRELAND US (IE) | 2018-04-17 | — | — | US | disclosed |
| US-20160237083-A1 | INDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN SCIENCES IRELAND UC (IE) | 2016-08-18 | — | — | US | disclosed |
| US-20160237083-A1 | INDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN SCIENCES IRELAND UC (IE) | 2016-08-18 | — | — | US | disclosed |
| US-20160237083-A1 | INDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN SCIENCES IRELAND UC (IE) | 2016-08-18 | — | — | US | disclosed |
| US-9321768-B2 | Indoles as respiratory syncytial virus antiviral agents | JANSSEN SCIENCES IRELAND UC (IE) | 2016-04-26 | — | — | US | disclosed |
| US-9321768-B2 | Indoles as respiratory syncytial virus antiviral agents | JANSSEN SCIENCES IRELAND UC (IE) | 2016-04-26 | — | — | US | disclosed |
| US-9321768-B2 | Indoles as respiratory syncytial virus antiviral agents | JANSSEN SCIENCES IRELAND UC (IE) | 2016-04-26 | — | — | US | disclosed |
| EP-2651922-B1 | INDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN SCIENCES IRELAND UC (IE) | 2016-02-24 | — | — | EP | disclosed |
| US-8921560-B2 | Indoles as respiratory syncytial virus antiviral agents | JANSSEN R&D IRELAND (IE) | 2014-12-30 | — | — | US | disclosed |
| US-8921560-B2 | Indoles as respiratory syncytial virus antiviral agents | JANSSEN R&D IRELAND (IE) | 2014-12-30 | — | — | US | disclosed |
| US-8921560-B2 | Indoles as respiratory syncytial virus antiviral agents | JANSSEN R&D IRELAND (IE) | 2014-12-30 | — | — | US | disclosed |
| EP-2651922-A1 | INDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | Janssen R&D Ireland (IE) | 2013-10-23 | — | — | EP | disclosed |
| US-20130267555-A1 | INDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN R&D IRELAND (IE) | 2013-10-10 | — | — | US | disclosed |
| US-20130267555-A1 | INDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN R&D IRELAND (IE) | 2013-10-10 | — | — | US | disclosed |
| US-20130267555-A1 | INDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN R&D IRELAND (IE) | 2013-10-10 | — | — | US | disclosed |
| CN-103347875-A | Indoles as respiratory syncytial virus antiviral agents | JANSSEN R & D IRELAND | 2013-10-09 | — | — | CN | disclosed |
| WO-2012080447-A1 | INDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN R&D IRELAND (IE) | 2012-06-21 | — | — | WO | disclosed |
| WO-2012080447-A1 | INDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN R&D IRELAND (IE) | 2012-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160237083-A1 | INDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | IDO1, IDO2, INMT | CYP3A4 81/4885OPRL1 4123/4885CYP2D6 409/4885 |
| US-20130267555-A1 | INDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | IDO1, IDO2, INMT | CYP3A4 81/4885OPRL1 4123/4885CYP2D6 409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.