Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | XBP1 | P17861 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | STAT1 | P42224 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28294733 | 0.80 | HDAC1 (0.53) | EPHX2NR1H4MAPTSMN1; SMN2RAB9A | |
| SCHEMBL22096914 | 0.79 | SMN1; SMN2 (0.62) | EPHX2NR1H4MAPTSMN1; SMN2RAB9A | |
| SCHEMBL13756246 | 0.78 | MAPT (0.81) | EPHX2NR1H4MAPTSMN1; SMN2RAB9A | |
| SCHEMBL2730172 | 0.78 | MAPT (0.81) | EPHX2NR1H4MAPTSMN1; SMN2RAB9A | |
| SCHEMBL6387783 | 0.76 | MAPT (0.62) | EPHX2NR1H4MAPTSMN1; SMN2RAB9A | |
| SCHEMBL12233865 | 0.75 | MAPT (0.58) | EPHX2NR1H4MAPTSMN1; SMN2RAB9A | |
| SCHEMBL17072026 | 0.75 | EPHX2 (0.74) | EPHX2NR1H4MAPTSMN1; SMN2RAB9A | |
| SCHEMBL9037064 | 0.75 | NPC1 (0.66) | EPHX2NR1H4MAPTSMN1; SMN2RAB9A | |
| SCHEMBL12264103 | 0.74 | RAB9A (0.65) | EPHX2NR1H4MAPTSMN1; SMN2RAB9A | |
| SCHEMBL21840834 | 0.74 | RAB9A (0.55) | EPHX2NR1H4MAPTSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2646455-A2 | MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2013-10-09 | — | — | EP | disclosed |
| WO-2012082436-A2 | MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2012-06-21 | — | — | WO | disclosed |