Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 5/20 | 0.71 |
| ▸ | PTGS2 | P35354 | 11/20 | 0.69 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.69 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.69 |
| ▸ | CA1 | P00915 | 3/20 | 0.58 |
| ▸ | CA2 | P00918 | 3/20 | 0.58 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6350558 | 0.85 | PTGS2 (0.66) | CA9PTGS2EPHX2PTGS1CA1 | |
| SCHEMBL6341958 | 0.83 | PTGS2 (0.67) | CA9PTGS2EPHX2PTGS1CA1 | |
| SCHEMBL9941851 | 0.83 | CA9 (1.00) | CA9PTGS2EPHX2PTGS1CA1 | |
| SCHEMBL6353808 | 0.81 | PTGS2 (0.70) | CA9PTGS2EPHX2PTGS1CA1 | |
| SCHEMBL6344713 | 0.80 | PTGS2 (0.63) | CA9PTGS2EPHX2PTGS1CA1 | |
| SCHEMBL6856152 | 0.80 | PTGS2 (0.63) | CA9PTGS2EPHX2PTGS1CA1 | |
| SCHEMBL15460595 | 0.79 | PTGS2 (0.75) | CA9PTGS2EPHX2PTGS1CA1 | |
| SCHEMBL8688440 | 0.79 | PTGS2 (0.61) | CA9PTGS2EPHX2PTGS1CA1 | |
| SCHEMBL5430597 | 0.78 | PTGS2 (0.59) | CA9PTGS2EPHX2PTGS1CA1 | |
| SCHEMBL6344046 | 0.78 | PTGS2 (0.66) | CA9PTGS2EPHX2PTGS1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9096532-B2 | Pyrazole inhibitors of COX-2 and sEH | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-08-04 | — | — | US | disclosed |
| US-9096532-B2 | Pyrazole inhibitors of COX-2 and sEH | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-08-04 | — | — | US | disclosed |
| US-9096532-B2 | Pyrazole inhibitors of COX-2 and sEH | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-08-04 | — | — | US | disclosed |
| US-20140038923-A1 | PYRAZOLE INHIBITORS OF COX-2 AND SEH | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-02-06 | — | — | US | disclosed |
| US-20140038923-A1 | PYRAZOLE INHIBITORS OF COX-2 AND SEH | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-02-06 | — | — | US | disclosed |
| US-20140038923-A1 | PYRAZOLE INHIBITORS OF COX-2 AND SEH | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-02-06 | — | — | US | disclosed |
| WO-2012082647-A2 | PYRAZOLE INHIBITORS OF COX-2 AND sEH | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140038923-A1 | PYRAZOLE INHIBITORS OF COX-2 AND SEH | PTGES2, PTGS2, PTGES3 | CA9 4178/4885PTGS2 2/4885EPHX2 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.