Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30370085 | 0.86 | L3MBTL1 (0.72) | L3MBTL1KDM4EALDH1A1NPSR1CYP2C19 | |
| SCHEMBL13905827 | 0.86 | L3MBTL1 (0.72) | L3MBTL1KDM4EALDH1A1NPSR1CYP2C19 | |
| SCHEMBL4387098 | 0.85 | L3MBTL1 (0.75) | L3MBTL1KDM4EALDH1A1NPSR1CYP2C19 | |
| Hydrochloric Acid SCHEMBL27515725 | 0.84 | L3MBTL1 (0.78) | L3MBTL1KDM4EALDH1A1NPSR1CYP2C19 | |
| SCHEMBL21061629 | 0.78 | L3MBTL1 (0.82) | L3MBTL1KDM4EALDH1A1NPSR1CYP2C19 | |
| SCHEMBL21061969 | 0.78 | L3MBTL1 (0.82) | L3MBTL1KDM4EALDH1A1NPSR1CYP2C19 | |
| SCHEMBL5841484 | 0.78 | L3MBTL1 (0.54) | L3MBTL1SIRT1KDM4ECYP2C19KMT2A | |
| SCHEMBL21061923 | 0.77 | L3MBTL1 (0.63) | L3MBTL1KDM4EALDH1A1CYP2C19SMN1; SMN2 | |
| SCHEMBL29500889 | 0.77 | L3MBTL1 (0.63) | L3MBTL1KDM4EALDH1A1CYP2C19SMN1; SMN2 | |
| SCHEMBL21061948 | 0.77 | L3MBTL1 (0.63) | L3MBTL1KDM4EALDH1A1CYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454257-A1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | Abbott Laboratories (US) | 2012-05-23 | — | — | EP | disclosed |
| WO-2011008915-A1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-01-20 | — | — | WO | disclosed |