Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | KAT7 | O95251 | 1/20 | 0.35 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9904146 | 0.81 | PIM1 (0.41) | PIM1PIM2USP30BRD4BCHE | |
| SCHEMBL9904144 | 0.81 | PIM1 (0.41) | PIM1PIM2USP30BRD4BCHE | |
| SCHEMBL9942550 | 0.79 | CHEK2 (0.37) | PIM1PIM2BCHEHTR6GPR119 | |
| SCHEMBL9904659 | 0.73 | PIM1 (0.53) | PIM1PIM2USP30HDAC4HDAC6 | |
| SCHEMBL9904658 | 0.73 | PIM1 (0.53) | PIM1PIM2USP30HDAC4HDAC6 | |
| SCHEMBL9904525 | 0.72 | PIK3CD (0.39) | PIM1PIM2USP30BRD4BCHE | |
| SCHEMBL9904528 | 0.72 | PIK3CD (0.39) | PIM1PIM2USP30BRD4BCHE | |
| SCHEMBL15446264 | 0.70 | PIM1 (0.39) | PIM1PIM2USP30BRD4BCHE | |
| SCHEMBL9904379 | 0.70 | PIM1 (0.39) | PIM1PIM2USP30BRD4BCHE | |
| SCHEMBL9942514 | 0.70 | PIM1 (0.39) | PIM1PIM2USP30BRD4BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012078777-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | AMGEN INC. (US) | 2012-06-14 | — | — | WO | disclosed |