Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9901268 | 0.82 | TYK2 (0.42) | CHEK2GPR119PRMT5BCHEHTR6 | |
| SCHEMBL9901269 | 0.82 | TYK2 (0.42) | CHEK2GPR119PRMT5BCHEHTR6 | |
| SCHEMBL9942533 | 0.79 | PIM1 (0.38) | GPR119BCHEHTR6PIM1PIM2 | |
| SCHEMBL9904399 | 0.74 | TYK2 (0.62) | CHEK2PIK3CDTYK2PIM1PIM3 | |
| SCHEMBL9904397 | 0.74 | TYK2 (0.62) | CHEK2PIK3CDTYK2PIM1PIM3 | |
| SCHEMBL9904423 | 0.71 | TYK2 (0.58) | CHEK2PIK3CDTYK2PIM1PIM3 | |
| SCHEMBL9905828 | 0.71 | TYK2 (0.58) | CHEK2PIK3CDTYK2PIM1PIM3 | |
| SCHEMBL9904379 | 0.67 | PIM1 (0.39) | GPR119BCHEHTR6PIM1PIM2 | |
| SCHEMBL15446264 | 0.67 | PIM1 (0.39) | GPR119BCHEHTR6PIM1PIM2 | |
| SCHEMBL9942514 | 0.67 | PIM1 (0.39) | GPR119BCHEHTR6PIM1PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012078777-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | AMGEN INC. (US) | 2012-06-14 | — | — | WO | disclosed |