Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 16/20 | 0.58 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9930630 | 0.87 | CCR2 (0.61) | CCR2BRAFKDM4EMEN1ALDH1A1 | |
| SCHEMBL9942779 | 0.80 | CCR2 (0.62) | CCR2BRAFALDH1A1 | |
| SCHEMBL16747623 | 0.78 | CCR2 (0.66) | CCR2BRAFMEN1KMT2A | |
| SCHEMBL9931224 | 0.77 | CCR2 (0.70) | CCR2BRAFMEN1KMT2A | |
| SCHEMBL9931094 | 0.76 | CCR2 (0.74) | CCR2BRAFALDH1A1 | |
| SCHEMBL9930923 | 0.76 | CCR2 (0.77) | CCR2BRAF | |
| SCHEMBL9930374 | 0.75 | CCR2 (0.79) | CCR2BRAFMEN1MAPTKMT2A | |
| SCHEMBL9931076 | 0.75 | CCR2 (0.67) | CCR2BRAFALDH1A1 | |
| SCHEMBL9930952 | 0.75 | CCR2 (0.62) | CCR2BRAF | |
| SCHEMBL9931260 | 0.75 | CCR2 (0.73) | CCR2BRAFMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651901-A1 | NOVEL 1,2- BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | Allergan, Inc. (US) | 2013-10-23 | — | — | EP | claimed |
| WO-2012082633-A1 | NOVEL 1,2- BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2012-06-21 | — | — | WO | claimed |
| EP-2651901-A1 | NOVEL 1,2- BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | Allergan, Inc. (US) | 2013-10-23 | — | — | EP | disclosed |
| WO-2012082633-A1 | NOVEL 1,2- BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2012-06-21 | — | — | WO | disclosed |