⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL632832 | 0.70 | LPL (0.31) | — | |
| SCHEMBL993855 | 0.65 | KCNH2 (0.44) | — | |
| SCHEMBL30776600 | 0.65 | GRM2 (0.32) | — | |
| SCHEMBL29956945 | 0.65 | CA1 (0.36) | — | |
| SCHEMBL28675408 | 0.65 | CA1 (0.36) | — | |
| SCHEMBL23832831 | 0.64 | — | — | |
| SCHEMBL30022201 | 0.64 | — | — | |
| SCHEMBL29957339 | 0.64 | MAPT (0.32) | — | |
| SCHEMBL3450325 | 0.64 | MAPT (0.32) | — | |
| SCHEMBL29953424 | 0.63 | SSTR4 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970332-B1 | CHEMICAL ENTITIES | FUNDACIÓN CENTRO NAC DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (ES) | 2018-02-28 | — | — | EP | disclosed |
| CN-104169277-B | Aurora kinase and flt3 kinase modulators | 赛勒姆公司 | 2016-10-12 | — | — | CN | disclosed |
| US-9453031-B2 | Chemical entities | FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (ES) | 2016-09-27 | — | — | US | disclosed |
| US-20160024112-A1 | CHEMICAL ENTITIES | FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (ES) | 2016-01-28 | — | — | US | disclosed |
| EP-2970332-A1 | CHEMICAL ENTITIES | Fundación Centro Nacional de Investigaciones Oncológicas Carlos III (ES) | 2016-01-20 | — | — | EP | disclosed |
| EP-2812328-B1 | AURORA AND FLT3 KINASES MODULATORS | SAREUM LTD (GB) | 2015-11-18 | — | — | EP | disclosed |
| EP-2812328-B1 | AURORA AND FLT3 KINASES MODULATORS | SAREUM LTD (GB) | 2015-11-18 | — | — | EP | disclosed |
| US-9133180-B2 | Aurora and FLT3 kinases modulators | SAREUM LIMITED (GB) | 2015-09-15 | — | — | US | disclosed |
| US-9133180-B2 | Aurora and FLT3 kinases modulators | SAREUM LIMITED (GB) | 2015-09-15 | — | — | US | disclosed |
| US-9133180-B2 | Aurora and FLT3 kinases modulators | SAREUM LIMITED (GB) | 2015-09-15 | — | — | US | disclosed |
| US-7893060-B2 | Thiazolopyrimidines and their use as inhibitors of phosphatidylinositol-3 kinase | F. HOFFMANN-LA ROCHE AG (GB) | 2011-02-22 | — | — | US | disclosed |
| US-7893060-B2 | Thiazolopyrimidines and their use as inhibitors of phosphatidylinositol-3 kinase | F. HOFFMANN-LA ROCHE AG (GB) | 2011-02-22 | — | — | US | disclosed |
| US-20110021496-A1 | THIENOPYRIMIDINE DERIVATIVES AS P13K INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-01-27 | — | — | US | disclosed |
| US-20110021496-A1 | THIENOPYRIMIDINE DERIVATIVES AS P13K INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-01-27 | — | — | US | disclosed |
| US-20110021496-A1 | THIENOPYRIMIDINE DERIVATIVES AS P13K INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-01-27 | — | — | US | disclosed |
| WO-2010136491-A1 | BICYCLIC INDOLE-PYRIMIDINE PI3K INHIBITOR COMPOUNDS SELECTIVE FOR P110 DELTA, AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2010-12-02 | — | — | WO | disclosed |
| US-20100305084-A1 | BICYCLIC INDOLE-PYRIMIDINE PI3K INHIBITOR COMPOUNDS SELECTIVE FOR P110 DELTA, AND METHODS OF USE | HOFFMAN-LA ROCHE INC. | 2010-12-02 | — | — | US | disclosed |
| US-20100190769-A1 | THIAZOLOPYRIMIDINES AND THEIR USE AS INHIBITORS OF PHOSPHATIDYLINOSITOL-3 KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2010-07-29 | — | — | US | disclosed |
| US-20100190769-A1 | THIAZOLOPYRIMIDINES AND THEIR USE AS INHIBITORS OF PHOSPHATIDYLINOSITOL-3 KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2010-07-29 | — | — | US | disclosed |
| WO-2008152390-A1 | THIAZOLIOPYRIMIDINES AND THEIR USE AS INHIBITORS OF PHOSPHATIDYLINOSITOL-3 KINASE | F.HOFFMANN-LA ROCHE AG (CH) | 2008-12-18 | — | — | WO | disclosed |