Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.43 |
| ▸ | TTBK1 | Q5TCY1 | 3/20 | 0.42 |
| ▸ | TTBK2 | Q6IQ55 | 3/20 | 0.42 |
| ▸ | STK4 | Q13043 | 2/20 | 0.40 |
| ▸ | STK3 | Q13188 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 2/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.38 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9928264 | 0.91 | STK4 (0.46) | EGFRERBB2TTBK1TTBK2STK4 | |
| SCHEMBL9898236 | 0.89 | TTBK1 (0.44) | EGFRTTBK1TTBK2STK4STK3 | |
| SCHEMBL9928304 | 0.83 | DRD4 (0.43) | TTBK1TTBK2STK4STK3CDC7 | |
| SCHEMBL9928317 | 0.83 | EGFR (0.51) | EGFRERBB2TTBK1TTBK2STK4 | |
| SCHEMBL9943144 | 0.83 | BRAF (0.45) | EGFRERBB2TTBK1TTBK2STK4 | |
| SCHEMBL9928319 | 0.83 | TTBK1 (0.42) | EGFRERBB2TTBK1TTBK2STK4 | |
| SCHEMBL9928318 | 0.82 | EGFR (0.48) | EGFRSTK4STK3BRAFTNNI3K | |
| SCHEMBL9928320 | 0.81 | EGFR (0.48) | EGFRERBB2TTBK1TTBK2STK4 | |
| SCHEMBL9943094 | 0.78 | EGFR (0.47) | EGFRERBB2TTBK1TTBK2STK4 | |
| SCHEMBL9928262 | 0.78 | EGFR (0.47) | EGFRERBB2TTBK1TTBK2STK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149902-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE | UBE INDUSTRIES, LTD. (JP) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149902-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE | ERBB2, EGFR, FGFR1 | EGFR 2/4885ERBB2 1/4885TTBK1 417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.