Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12130583 | 0.87 | SLC6A4 (0.50) | SLC6A2SLC6A3HRH3SLC6A4LMNA | |
| SCHEMBL12130507 | 0.87 | HRH3 (0.52) | SLC6A2SLC6A3HRH3SLC6A4MEN1 | |
| SCHEMBL992649 | 0.85 | HRH3 (0.40) | SLC6A2SLC6A3HRH3SLC6A4TSHR | |
| SCHEMBL12130610 | 0.85 | SLC6A3 (0.45) | SLC6A2SLC6A3HRH3SLC6A4MEN1 | |
| SCHEMBL12130553 | 0.85 | SLC6A2 (0.42) | SLC6A2SLC6A3HRH3SLC6A4MEN1 | |
| SCHEMBL994992 | 0.85 | SLC6A4 (0.48) | SLC6A2SLC6A3HRH3SLC6A4MEN1 | |
| SCHEMBL12130554 | 0.84 | HRH3 (0.43) | SLC6A2SLC6A3HRH3SLC6A4LTA4H | |
| SCHEMBL12130449 | 0.84 | HRH3 (0.43) | SLC6A2SLC6A3HRH3SLC6A4LTA4H | |
| SCHEMBL12130611 | 0.83 | LTA4H (0.47) | SLC6A2SLC6A3HRH3SLC6A4KMT2A | |
| SCHEMBL12130604 | 0.83 | HRH3 (0.46) | SLC6A2SLC6A3HRH3LMNALTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7910605-B2 | Non-imidazole alkylamines as histamine H3- receptor ligands and their therapeutic applications | SOCIETE CIVILE BIOPROJET (FR) | 2011-03-22 | — | — | US | disclosed |
| WO-2011008666-A2 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | THERAVANCE, INC. (US) | 2011-01-20 | — | — | WO | disclosed |