SCHEMBL9944500

SCHEMBL9944500

O=C(Nc1ccccc1)C1CC1C(=O)Nc1ccccc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.65
TDP1 Q9NUW8 1/20 0.65
L3MBTL1 Q9Y468 1/20 0.64
MAPT P10636 3/20 0.61
SMN1; SMN2 Q16637 3/20 0.61
MEN1 O00255 3/20 0.61
KMT2A Q03164 3/20 0.61
HPGD P15428 2/20 0.61
RAB9A P51151 2/20 0.61
NPC1 O15118 1/20 0.61
GAA P10253 3/20 0.57
DEGS1 O15121 1/20 0.57
PARP1 P09874 1/20 0.57
PARP10 Q53GL7 1/20 0.57
GFER P55789 1/20 0.56
LMNA P02545 2/20 0.56
NAMPT P43490 1/20 0.56
ALDH1A1 P00352 1/20 0.56
HTT P42858 1/20 0.56
TP53 P04637 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9946340 0.91 L3MBTL1 (0.69) POLBTDP1L3MBTL1MAPTSMN1; SMN2
SCHEMBL16602956 0.91 POLB (0.56) POLBTDP1L3MBTL1MAPTSMN1; SMN2
SCHEMBL11861632 0.88 POLB (0.61) POLBTDP1L3MBTL1MAPTSMN1; SMN2
SCHEMBL23992767 0.86 SMN1; SMN2 (0.81) POLBTDP1L3MBTL1MAPTSMN1; SMN2
SCHEMBL18214318 0.86 SMN1; SMN2 (0.81) POLBTDP1L3MBTL1MAPTSMN1; SMN2
SCHEMBL105931 0.83 MAPT (0.78) POLBTDP1L3MBTL1MAPTSMN1; SMN2
SCHEMBL10337750 0.83 MAPT (0.78) POLBTDP1L3MBTL1MAPTSMN1; SMN2
SCHEMBL15706299 0.83 DEGS1 (0.82) TDP1MAPTSMN1; SMN2MEN1KMT2A
SCHEMBL960402 0.82 POLB (0.59) POLBTDP1L3MBTL1MAPTSMN1; SMN2
SCHEMBL5792805 0.81 POLB (0.54) POLBTDP1L3MBTL1MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2592095-B1 POLYSACCHARIDE DERIVATIVE, METHOD FOR PRODUCING THE SAME, AND SEPARATING AGENT DAICEL CORP (JP) 2017-05-24 EP disclosed
US-9562121-B2 Optically active poly(diphenylacetylene) compound, preparation method therefor, and use thereof as optical isomer separating agent NATIONAL UNIVERSITY CORPORATION KANAZAWA UNIVERSITY (JP) 2017-02-07 US disclosed
US-9562121-B2 Optically active poly(diphenylacetylene) compound, preparation method therefor, and use thereof as optical isomer separating agent NATIONAL UNIVERSITY CORPORATION KANAZAWA UNIVERSITY (JP) 2017-02-07 US disclosed
US-9499638-B2 Polysaccharide derivative and separating agent for optical isomer containing the same DAICEL CORPORATION (JP) 2016-11-22 US disclosed
US-9458186-B2 Polysaccharide derivative, method for producing the same, and separating agent DAICEL CORPORATION (JP) 2016-10-04 US disclosed
US-20150376308-A1 OPTICALLY ACTIVE POLY(DIPHENYLACETYLENE) COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF AS OPTICAL ISOMER SEPARATING AGENT NATIONAL UNIVERSITY CORPORATION KANAZAWA UNIVERSITY (JP) 2015-12-31 US disclosed
US-20150376308-A1 OPTICALLY ACTIVE POLY(DIPHENYLACETYLENE) COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF AS OPTICAL ISOMER SEPARATING AGENT NATIONAL UNIVERSITY CORPORATION KANAZAWA UNIVERSITY (JP) 2015-12-31 US disclosed
EP-2957575-A1 OPTICALLY ACTIVE POLY(DIPHENYLACETYLENE) COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF AS OPTICAL ISOMER SEPARATING AGENT National University Corporation Kanazawa University (JP) 2015-12-23 EP disclosed
US-20150141241-A1 SEPARATING AGENT FOR OPTICAL ISOMER National University Corporation Nagoya University a corporation 2015-05-21 US disclosed
EP-1887354-B1 PROCESS FOR PRODUCING A BEAD FOR OPTICAL-ISOMER RESOLUTION UNIV NAGOYA NAT UNIV CORP (JP) 2015-04-01 EP disclosed
US-20120149851-A1 SEPARATING AGENT FOR OPTICAL ISOMERS NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) 2012-06-14 US disclosed
US-7772382-B2 Chitosan derivative and method of producing same NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) 2010-08-10 US disclosed
US-7745616-B2 Bead for enantiomeric isomer resolution and process for producing the same National University Corporation, Nagoya University (JP) 2010-06-29 US disclosed
EP-1618949-B1 AGENT FOR SEPARATING OPTICAL ISOMERS DAICEL CHEM (JP) 2010-06-16 EP disclosed
US-7683167-B2 Separating agent for enantiomeric isomers DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 2010-03-23 US disclosed
US-7683167-B2 Separating agent for enantiomeric isomers DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 2010-03-23 US disclosed
US-20090068468-A1 Bead for Enantiomeric Isomer Resolution and Process for Producing the Same DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 2009-03-12 US disclosed
US-20090062519-A1 Chitosan Derivative and Method of Producing Same DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 2009-03-05 US disclosed
US-20070039890-A1 Separating agent for enantiomeric isomers DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 2007-02-22 US disclosed
US-20070039890-A1 Separating agent for enantiomeric isomers DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 2007-02-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090068468-A1 Bead for Enantiomeric Isomer Resolution and Process for Producing the Same AGL, F7, ALG1 POLB 516/4885TDP1 1785/4885L3MBTL1 4306/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.