⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1759108 | 0.91 | CA1 (0.30) | — | |
| SCHEMBL12958546 | 0.89 | LMNA (0.33) | — | |
| SCHEMBL12958561 | 0.89 | LMNA (0.33) | — | |
| SCHEMBL10151491 | 0.89 | LMNA (0.33) | — | |
| SCHEMBL12868816 | 0.89 | LMNA (0.33) | — | |
| SCHEMBL10151493 | 0.89 | LMNA (0.33) | — | |
| SCHEMBL10151492 | 0.89 | LMNA (0.33) | — | |
| SCHEMBL12958557 | 0.89 | LMNA (0.33) | — | |
| SCHEMBL12958543 | 0.89 | LMNA (0.33) | — | |
| SCHEMBL7925091 | 0.89 | LMNA (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8808681-B2 | Crosslinked, degradable polymers and uses thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2014-08-19 | — | — | US | disclosed |
| US-8562966-B2 | End-modified poly(beta-amino esters) and uses thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-10-22 | — | — | US | disclosed |
| US-20120149630-A1 | END-MODIFIED POLY(BETA-AMINO ESTERS) AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2012-06-14 | — | — | US | disclosed |
| US-20080242626-A1 | End-Modified Poly(beta-amino esters) and Uses Thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2008-10-02 | — | — | US | disclosed |
| US-20080145338-A1 | Acrylate-terminated poly(beta-amino esters); high throughput assay; biocompatability | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-06-19 | — | — | US | disclosed |