Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12958542 | 1.00 | LMNA (0.33) | LMNA | |
| SCHEMBL12958543 | 1.00 | LMNA (0.33) | LMNA | |
| SCHEMBL10151490 | 1.00 | LMNA (0.33) | LMNA | |
| SCHEMBL12958557 | 1.00 | LMNA (0.33) | LMNA | |
| SCHEMBL12868816 | 1.00 | LMNA (0.33) | LMNA | |
| SCHEMBL12958561 | 1.00 | LMNA (0.33) | LMNA | |
| SCHEMBL12958546 | 1.00 | LMNA (0.33) | LMNA | |
| SCHEMBL10151493 | 1.00 | LMNA (0.33) | LMNA | |
| SCHEMBL10151492 | 1.00 | LMNA (0.33) | LMNA | |
| SCHEMBL7925091 | 1.00 | LMNA (0.33) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210369866-A1 | BIODEGRADABLE LIPIDS FOR DELIVERY OF NUCLEIC ACIDS | TRANSLATE BIO, INC. | 2021-12-02 | — | — | US | disclosed |
| US-20210101875-A1 | AMINOALCOHOL LIPIDOIDS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2021-04-08 | — | — | US | disclosed |
| US-10959953-B2 | Lipid formulations for delivery of messenger RNA | TRANSLATE BIO, INC. (US) | 2021-03-30 | — | — | US | disclosed |
| US-10933139-B2 | Conjugated lipomers and uses thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2021-03-02 | — | — | US | disclosed |
| US-10912844-B2 | Biodegradable lipids for delivery of nucleic acids | TRANSLATE BIO, INC. (US) | 2021-02-09 | — | — | US | disclosed |
| US-10844028-B2 | Aminoalcohol lipidoids and uses thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2020-11-24 | — | — | US | disclosed |
| US-20200222558-A1 | BIODEGRADABLE LIPIDS FOR DELIVERY OF NUCLEIC ACIDS | RANA THERAPEUTICS, INC. | 2020-07-16 | — | — | US | disclosed |
| US-10682374-B2 | Amino acid-, peptide- and polypeptide-lipids, isomers, compositions, and uses thereof | MASSACHUSETTS INTSTITUTE OF TECHNOLOGY (US) | 2020-06-16 | — | — | US | disclosed |
| US-20190177289-A1 | AMINOALCOHOL LIPIDOIDS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2019-06-13 | — | — | US | disclosed |
| US-20190167795-A1 | CONJUGATED LIPOMERS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2019-06-06 | — | — | US | disclosed |
| US-20150140070-A1 | LIPID FORMULATIONS FOR DELIVERY OF MESSENGER RNA | TRANSLATE BIO, INC. | 2015-05-21 | — | — | US | disclosed |
| US-8969353-B2 | Aminoalcohol lipidoids and uses thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-03-03 | — | — | US | disclosed |
| US-20140322309-A1 | ALPHA-AMINOAMIDINE POLYMERS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLO (US) | 2014-10-30 | — | — | US | disclosed |
| US-20130302401-A1 | POLY(BETA-AMINO ALCOHOLS), THEIR PREPARATION, AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-11-14 | — | — | US | disclosed |
| US-20130158021-A1 | AMINO ACID-, PEPTIDE-AND POLYPEPTIDE-LIPIDS, ISOMERS, COMPOSITIONS, AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-06-20 | — | — | US | disclosed |
| US-8450298-B2 | Aminoalcohol lipidoids and uses thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-05-28 | — | — | US | disclosed |
| US-20120251560-A1 | CONJUGATED LIPOMERS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2012-10-04 | — | — | US | disclosed |
| WO-2012027675-A2 | POLY(BETA-AMINO ALCOHOLS), THEIR PREPARATION, AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2012-03-01 | — | — | WO | disclosed |
| US-20110293703-A1 | AMINOALCOHOL LIPIDOIDS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2011-12-01 | — | — | US | disclosed |
| US-20100331234-A1 | AMINOALCOHOL LIPIDOIDS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (16 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10959953-B2 | Lipid formulations for delivery of messenger RNA | RNMT, NSUN3, IGF2BP3 | LMNA 436/4885 |
| US-20210369866-A1 | BIODEGRADABLE LIPIDS FOR DELIVERY OF NUCLEIC ACIDS | LIPA, SLC67A1, SREBF1 | LMNA 411/4885 |
| US-20140322309-A1 | ALPHA-AMINOAMIDINE POLYMERS AND USES THEREOF | AAAS, AADAT, INMT | LMNA 136/4885 |
| US-20110293703-A1 | AMINOALCOHOL LIPIDOIDS AND USES THEREOF | PHOSPHO1, PNMT, AASDHPPT | LMNA 314/4885 |
| US-20190167795-A1 | CONJUGATED LIPOMERS AND USES THEREOF | EZH2, LIPC, PUF60 | LMNA 1562/4885 |
| US-10912844-B2 | Biodegradable lipids for delivery of nucleic acids | LIPA, SLC67A1, SREBF1 | LMNA 411/4885 |
| US-20190177289-A1 | AMINOALCOHOL LIPIDOIDS AND USES THEREOF | PHOSPHO1, PNMT, AASDHPPT | LMNA 314/4885 |
| US-20210101875-A1 | AMINOALCOHOL LIPIDOIDS AND USES THEREOF | PHOSPHO1, PNMT, AASDHPPT | LMNA 314/4885 |
| US-20120251560-A1 | CONJUGATED LIPOMERS AND USES THEREOF | EZH2, LIPC, PUF60 | LMNA 1562/4885 |
| US-20150140070-A1 | LIPID FORMULATIONS FOR DELIVERY OF MESSENGER RNA | RNMT, NSUN3, IGF2BP3 | LMNA 436/4885 |
| US-20200222558-A1 | BIODEGRADABLE LIPIDS FOR DELIVERY OF NUCLEIC ACIDS | LIPA, SLC67A1, SREBF1 | LMNA 411/4885 |
| US-10933139-B2 | Conjugated lipomers and uses thereof | EZH2, LIPC, PUF60 | LMNA 1562/4885 |
| US-20100331234-A1 | AMINOALCOHOL LIPIDOIDS AND USES THEREOF | PHOSPHO1, PNMT, AASDHPPT | LMNA 314/4885 |
| US-10844028-B2 | Aminoalcohol lipidoids and uses thereof | PHOSPHO1, PNMT, AASDHPPT | LMNA 314/4885 |
| US-20130158021-A1 | AMINO ACID-, PEPTIDE-AND POLYPEPTIDE-LIPIDS, ISOMERS, COMPOSITIONS, AND USES THEREOF | APLNR, NPPA, ARGLU1 | LMNA 1632/4885 |
| US-10682374-B2 | Amino acid-, peptide- and polypeptide-lipids, isomers, compositions, and uses thereof | APLNR, NPPA, ARGLU1 | LMNA 1632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.