Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | ALDH5A1 | P51649 | 2/20 | 0.32 |
| ▸ | ABAT | P80404 | 2/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.31 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.31 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1619086 | 0.80 | KDM4E (0.58) | KDM4ESRCPTGS2RAB9AALDH5A1 | |
| SCHEMBL9945981 | 0.78 | ALDH1A3 (0.47) | KDM4EERN1ALDH1A1 | |
| SCHEMBL14362718 | 0.76 | KDM4E (0.67) | KDM4EPTGS2RAB9AALDH5A1ABAT | |
| SCHEMBL9945982 | 0.76 | ERN1 (0.39) | PTGS2RAB9AERN1ALDH1A1HPGD | |
| SCHEMBL11380285 | 0.75 | KDM4E (0.58) | KDM4ESRCPTGS2RAB9AALDH5A1 | |
| SCHEMBL308093 | 0.72 | ALDH1A1 (0.47) | KDM4ESRCPTGS2RAB9AALDH5A1 | |
| SCHEMBL1072576 | 0.71 | KDM4E (0.48) | KDM4ESRCPTGS2RAB9AERN1 | |
| SCHEMBL9301841 | 0.67 | KDM4E (0.48) | KDM4EPTGS2RAB9AERN1ALDH1A1 | |
| SCHEMBL1771343 | 0.67 | KDM4E (0.48) | KDM4EPTGS2RAB9AERN1 | |
| SCHEMBL4655558 | 0.67 | KDM4E (0.48) | KDM4EPTGS2RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149693-A1 | THERAPEUTIC COMPOUNDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149693-A1 | THERAPEUTIC COMPOUNDS | HTR2C, GRK2, GRK3 | KDM4E 4270/4885SRC 1082/4885PTGS2 307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.