Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | STAT1 | P42224 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL488607 | 0.85 | TSHR (0.46) | SMN1; SMN2RAB9ANPC1MAPK1MAPT | |
| SCHEMBL21816954 | 0.83 | MAPK1 (0.41) | SMN1; SMN2RAB9ANPC1MAPK1LMNA | |
| SCHEMBL17863581 | 0.81 | MAPK1 (0.37) | SMN1; SMN2RAB9ANPC1MAPK1KMT2A | |
| SCHEMBL9946139 | 0.79 | ALDH1A1 (0.44) | SMN1; SMN2RAB9ANPC1MAPK1MAPT | |
| SCHEMBL23063924 | 0.77 | SMN1; SMN2 (0.50) | SMN1; SMN2RAB9ANPC1L3MBTL1MAPT | |
| SCHEMBL9946133 | 0.77 | POLB (0.41) | SMN1; SMN2RAB9ANPC1MAPK1L3MBTL1 | |
| SCHEMBL4623636 | 0.76 | KMT2A (0.43) | SMN1; SMN2RAB9ANPC1MAPK1L3MBTL1 | |
| SCHEMBL23063803 | 0.75 | SMN1; SMN2 (0.41) | SMN1; SMN2RAB9ANPC1MAPK1MAPT | |
| SCHEMBL1429353 | 0.74 | SMN1; SMN2 (0.56) | SMN1; SMN2RAB9ANPC1MAPK1L3MBTL1 | |
| SCHEMBL9946167 | 0.74 | HPGD (0.59) | MAPK1L3MBTL1HPGDKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149693-A1 | THERAPEUTIC COMPOUNDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149693-A1 | THERAPEUTIC COMPOUNDS | HTR2C, GRK2, GRK3 | SMN1; SMN2 3273/4885RAB9A 1191/4885NPC1 1529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.