Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 15/20 | 0.45 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | SPR | P35270 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9946588 | 0.89 | PTGES (0.47) | PTGESCFTRSPRGSK3BDYRK1A | |
| SCHEMBL9946853 | 0.84 | PTGES (0.46) | PTGESCFTRSPR | |
| SCHEMBL9898794 | 0.84 | PTGES (0.48) | PTGESCFTR | |
| SCHEMBL9946662 | 0.83 | CFTR (0.38) | PTGESCFTRSPR | |
| SCHEMBL9899353 | 0.82 | PTGES (0.49) | PTGES | |
| SCHEMBL9946866 | 0.82 | PTGES (0.49) | PTGES | |
| SCHEMBL9946760 | 0.80 | PTGES (0.45) | PTGES | |
| SCHEMBL9946592 | 0.80 | PTGES (0.45) | PTGES | |
| SCHEMBL9944811 | 0.78 | RAB9A (0.42) | PTGES | |
| SCHEMBL9945005 | 0.78 | RAB9A (0.42) | PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012076673-A1 | 6-AMINO-2-PHENYLAMINO-1H-BENZIMIDAZOLE-5-CARBOXAMIDE- DERIVATIVES AND THEIR USE AS MICROSOMAL PROSTAGLANDIN E2 SYNTHASE-1 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-14 | — | — | WO | disclosed |