Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2031946 | 0.78 | CNR2 (0.36) | KDM4EUSP2MEN1MAPTKMT2A | |
| SCHEMBL9947969 | 0.77 | KDM4E (0.35) | KDM4EUSP2MEN1MAPTKMT2A | |
| SCHEMBL9947718 | 0.72 | KDM4E (0.36) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL11839787 | 0.71 | KDM4E (0.48) | KDM4EUSP2MEN1MAPTKMT2A | |
| SCHEMBL9947711 | 0.71 | KDM4E (0.54) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL2834290 | 0.70 | MEN1 (0.49) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL28801578 | 0.68 | LMNA (0.47) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL9948011 | 0.68 | CNR2 (0.36) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL9947700 | 0.68 | CNR2 (0.36) | KDM4EMEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL2829434 | 0.68 | CNR2 (0.44) | KDM4EMEN1MAPTKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513061-A1 | PYRIDONE DERIVATIVES AS NK3 ANTAGONISTS | H. Lundbeck A/S (DK) | 2012-10-24 | — | — | EP | claimed |
| US-8207347-B2 | Pyridone derivatives as NK3 antagonists | H. LUNDBECK A/S (DK) | 2012-06-26 | — | — | US | claimed |
| EP-2513061-A1 | PYRIDONE DERIVATIVES AS NK3 ANTAGONISTS | H. Lundbeck A/S (DK) | 2012-10-24 | — | — | EP | disclosed |
| US-8207347-B2 | Pyridone derivatives as NK3 antagonists | H. LUNDBECK A/S (DK) | 2012-06-26 | — | — | US | disclosed |