Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | PTGFR | P43088 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9947581 | 0.85 | NOTUM (0.47) | NOTUMGAAGFERL3MBTL1MEN1 | |
| SCHEMBL9948181 | 0.81 | GAA (0.48) | NOTUMGAAGFERL3MBTL1PKM | |
| SCHEMBL9947669 | 0.76 | MEN1 (0.49) | NOTUMGAAGFERL3MBTL1PKM | |
| SCHEMBL1976606 | 0.74 | NOTUM (0.54) | NOTUMGAAGFERL3MBTL1MEN1 | |
| SCHEMBL2035472 | 0.74 | GAA (0.50) | NOTUMGAAGFERL3MBTL1PKM | |
| SCHEMBL9947638 | 0.74 | MEN1 (0.50) | NOTUMGAAGFERL3MBTL1PKM | |
| SCHEMBL3631255 | 0.74 | L3MBTL1 (0.46) | NOTUMGAAGFERL3MBTL1KDM4E | |
| SCHEMBL2676134 | 0.74 | GAA (0.45) | NOTUMGAAGFERL3MBTL1KDM4E | |
| SCHEMBL9947824 | 0.74 | GAA (0.47) | NOTUMGAAGFERL3MBTL1MEN1 | |
| SCHEMBL1718433 | 0.73 | GAA (0.60) | NOTUMGAAGFERL3MBTL1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513061-A1 | PYRIDONE DERIVATIVES AS NK3 ANTAGONISTS | H. Lundbeck A/S (DK) | 2012-10-24 | — | — | EP | claimed |
| US-8207347-B2 | Pyridone derivatives as NK3 antagonists | H. LUNDBECK A/S (DK) | 2012-06-26 | — | — | US | claimed |
| EP-2513061-A1 | PYRIDONE DERIVATIVES AS NK3 ANTAGONISTS | H. Lundbeck A/S (DK) | 2012-10-24 | — | — | EP | disclosed |
| US-8207347-B2 | Pyridone derivatives as NK3 antagonists | H. LUNDBECK A/S (DK) | 2012-06-26 | — | — | US | disclosed |