Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9949154 | 0.73 | HTR2A (0.36) | SMN1; SMN2RIPK1 | |
| SCHEMBL9948785 | 0.69 | PLK1 (0.33) | RIPK1 | |
| SCHEMBL22104901 | 0.69 | CYP2D6 (0.46) | RIPK1 | |
| SCHEMBL9948513 | 0.65 | JAK3 (0.41) | SMN1; SMN2RIPK1 | |
| SCHEMBL9948893 | 0.64 | JAK3 (0.44) | SMN1; SMN2RIPK1 | |
| SCHEMBL9948612 | 0.62 | ADORA3 (0.40) | — | |
| SCHEMBL22104899 | 0.61 | CYP2D6 (0.51) | SMN1; SMN2RIPK1 | |
| SCHEMBL24922545 | 0.60 | NPC1 (0.49) | SMN1; SMN2RIPK1 | |
| SCHEMBL388299 | 0.60 | — | — | |
| SCHEMBL30592189 | 0.59 | ALDH1A1 (0.36) | SMN1; SMN2RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165334-A1 | Indole/Benzimidazole Compounds as mTOR Kinase Inhibitors | AMGEN INC. (US) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165334-A1 | Indole/Benzimidazole Compounds as mTOR Kinase Inhibitors | MTOR, PIKFYVE, RICTOR | SMN1; SMN2 3660/4885RIPK1 258/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.