Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | PRKCA | P17252 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10188802 | 1.00 | OPRK1 (0.36) | OPRK1NPC1SLC6A2LMNAPRKCA | |
| SCHEMBL9950559 | 0.89 | NPC1 (0.35) | OPRK1NPC1SLC6A2LMNASLC6A4 | |
| SCHEMBL10188807 | 0.89 | NPC1 (0.35) | OPRK1NPC1SLC6A2LMNASLC6A4 | |
| SCHEMBL9950971 | 0.75 | NPC1 (0.31) | OPRK1NPC1SLC6A4OPRM1SLC22A1 | |
| SCHEMBL10188803 | 0.74 | NPC1 (0.36) | OPRK1NPC1SLC6A2LMNASLC6A4 | |
| SCHEMBL28055529 | 0.70 | OPRM1 (0.34) | OPRK1NPC1SLC6A2LMNASLC6A4 | |
| SCHEMBL13720493 | 0.67 | SLC6A2 (0.39) | OPRK1SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL13720351 | 0.67 | IDO1 (0.42) | — | |
| SCHEMBL9951858 | 0.66 | CYP3A4 (0.37) | OPRK1SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL14145380 | 0.66 | ATM (0.41) | NPC1LMNAPRKCANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165339-A1 | CYCLOPROPANE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165339-A1 | CYCLOPROPANE DERIVATIVES | HCRTR2, HCRTR1, CNR1 | OPRK1 61/4885NPC1 710/4885SLC6A2 784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.