Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 10/20 | 0.56 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 6/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 2/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 5/20 | 0.36 |
| ▸ | EGFR | P00533 | 4/20 | 0.36 |
| ▸ | ABL2 | P42684 | 4/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | NPM1 | P06748 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | LYN | P07948 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1442815 | 1.00 | ADK (0.56) | ADKSLC29A1SRCRIPK2RET | |
| SCHEMBL16236390 | 0.89 | ADK (0.54) | ADKSLC29A1SRCRIPK2RET | |
| SCHEMBL29484542 | 0.89 | ADK (0.54) | ADKSLC29A1SRCRIPK2RET | |
| SCHEMBL398110 | 0.88 | ADK (0.57) | ADKSLC29A1SRCRETMTOR | |
| SCHEMBL398109 | 0.88 | ADK (0.57) | ADKSLC29A1SRCRETMTOR | |
| SCHEMBL398720 | 0.88 | ADK (0.57) | ADKSLC29A1SRCRETMTOR | |
| SCHEMBL9950833 | 0.85 | ADK (0.55) | ADKSLC29A1SRCRETMTOR | |
| SCHEMBL9950831 | 0.85 | ADK (0.55) | ADKSLC29A1SRCRETMTOR | |
| SCHEMBL9951321 | 0.85 | SRC (0.53) | ADKSRCRIPK2RETMTOR | |
| SCHEMBL1442499 | 0.85 | SRC (0.53) | ADKSRCRIPK2RETMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165310-A1 | ETHER DERIVATIVES OF BICYCLIC HETEROARYLS | NOVARTIS AG (CH) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165310-A1 | ETHER DERIVATIVES OF BICYCLIC HETEROARYLS | ETV6, CYP11B2, CYP11B1 | ADK 3449/4885SLC29A1 1922/4885SRC 292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.