Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15012409 | 0.93 | MEN1 (0.50) | MEN1KMT2APOLBL3MBTL1ALDH1A1 | |
| SCHEMBL8264868 | 0.86 | ALDH1A1 (0.63) | MEN1KMT2AL3MBTL1ALDH1A1GAA | |
| SCHEMBL695065 | 0.81 | MEN1 (0.68) | MEN1KMT2APOLBL3MBTL1ALDH1A1 | |
| SCHEMBL13132109 | 0.80 | KMT2A (0.39) | MEN1KMT2APOLBL3MBTL1ALDH1A1 | |
| SCHEMBL4692148 | 0.80 | ALDH1A1 (0.42) | MEN1KMT2APOLBL3MBTL1ALDH1A1 | |
| SCHEMBL13132115 | 0.79 | KMT2A (0.43) | MEN1KMT2APOLBALDH1A1GAA | |
| SCHEMBL17471287 | 0.79 | MEN1 (0.44) | MEN1KMT2APOLBL3MBTL1GAA | |
| SCHEMBL13132347 | 0.78 | MEN1 (0.48) | MEN1KMT2APOLBL3MBTL1ALDH1A1 | |
| SCHEMBL13132114 | 0.78 | MEN1 (0.39) | MEN1KMT2APOLBL3MBTL1ALDH1A1 | |
| SCHEMBL1566337 | 0.76 | ALDH1A1 (0.64) | MEN1KMT2APOLBL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085935-A2 | COMPOUNDS AS INHIBITORS OF RENIN | CADILA HEALTHCARE LIMITED (IN) | 2012-06-28 | — | — | WO | disclosed |