Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL695344 | 0.85 | PKM (0.57) | KDM4EALDH1A1PLAUMAPK1L3MBTL1 | |
| SCHEMBL6838654 | 0.80 | MCL1 (0.46) | KDM4EALDH1A1MCL1TDP1 | |
| SCHEMBL3079622 | 0.80 | THRA (0.48) | MCL1 | |
| SCHEMBL19338375 | 0.80 | PKM (0.62) | ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL16510360 | 0.80 | KDM4E (0.49) | KDM4ETDP1MAPTHPGD | |
| SCHEMBL2341095 | 0.78 | KMT2A (0.55) | L3MBTL1 | |
| SCHEMBL1023516 | 0.78 | THRA (0.59) | KDM4EALDH1A1MCL1SMN1; SMN2 | |
| SCHEMBL5191841 | 0.77 | PDE3B (0.44) | KDM4EALDH1A1TDP1L3MBTL1 | |
| SCHEMBL16909329 | 0.77 | THRA (0.48) | ALDH1A1MCL1L3MBTL1 | |
| SCHEMBL694983 | 0.77 | MAPT (0.67) | KDM4EALDH1A1TDP1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085935-A2 | COMPOUNDS AS INHIBITORS OF RENIN | CADILA HEALTHCARE LIMITED (IN) | 2012-06-28 | — | — | WO | disclosed |