Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | BRAF | P15056 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.48 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.48 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | CASR | P41180 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9951815 | 0.95 | KDR (0.50) | KDRBRAFEGFRLMNAMAPT | |
| SCHEMBL19805596 | 0.92 | KDR (0.50) | KDRBRAFEGFRLMNAMAPT | |
| SCHEMBL18804919 | 0.92 | KDR (0.48) | KDRBRAFEGFRLMNAMAPT | |
| SCHEMBL9952083 | 0.92 | RXFP1 (0.50) | KDRLMNAMAPTGAARAB9A | |
| SCHEMBL17154497 | 0.89 | LMNA (0.52) | KDRLMNAMAPTGAARAB9A | |
| SCHEMBL22339738 | 0.89 | LMNA (0.57) | KDRLMNAMAPTGAARAB9A | |
| SCHEMBL9951429 | 0.89 | RXFP1 (0.49) | KDRLMNAMAPTGAARAB9A | |
| SCHEMBL31376514 | 0.89 | RXFP1 (0.49) | KDRLMNAMAPTGAARAB9A | |
| SCHEMBL29677914 | 0.89 | RXFP1 (0.49) | KDRLMNAMAPTGAARAB9A | |
| SCHEMBL10067171 | 0.88 | LMNA (0.53) | KDRLMNAMAPTGAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230165813-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2023-06-01 | — | — | US | disclosed |
| US-20220127232-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND COMPOSITIONS AND USES THEREOF | APPIA PHARMACEUTICALS LLC | 2022-04-28 | — | — | US | disclosed |
| US-20200330410-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2020-10-22 | — | — | US | disclosed |
| EP-3323813-B1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | UNIV COLUMBIA (US) | 2020-08-26 | — | — | EP | disclosed |
| EP-3323813-B1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | UNIV COLUMBIA (US) | 2020-08-26 | — | — | EP | disclosed |
| US-10653648-B2 | Histone acetyltransferase activators and compositions and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-05-19 | — | — | US | disclosed |
| US-20180244603-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2018-08-30 | — | — | US | disclosed |
| EP-3323813-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | The Trustees of Columbia University in the City of New York (US) | 2018-05-23 | — | — | EP | disclosed |
| EP-3323813-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | The Trustees of Columbia University in the City of New York (US) | 2018-05-23 | — | — | EP | disclosed |
| US-9969677-B2 | Histone acetyltransferase modulators and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-05-15 | — | — | US | disclosed |
| US-9969677-B2 | Histone acetyltransferase modulators and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-05-15 | — | — | US | disclosed |
| EP-2654428-B1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USESE THEREOF | UNIV COLUMBIA (US) | 2018-02-14 | — | — | EP | disclosed |
| EP-2654428-B1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USESE THEREOF | UNIV COLUMBIA (US) | 2018-02-14 | — | — | EP | disclosed |
| US-20180021273-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2018-01-25 | — | — | US | disclosed |
| WO-2018017858-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-01-25 | — | — | WO | disclosed |
| US-20170121276-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-05-04 | — | — | US | disclosed |
| US-20170121276-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-05-04 | — | — | US | disclosed |
| EP-2654428-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USESE THEREOF | The Trustees of Columbia University in the City of New York (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012088420-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USESE THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012088420-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USESE THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180021273-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | HDAC6, HDAC9, HDAC5 | KDR 4817/4885BRAF 2396/4885EGFR 4094/4885 |
| US-20220127232-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND COMPOSITIONS AND USES THEREOF | EP300, KAT2A, NAA40 | KDR 4837/4885BRAF 3067/4885EGFR 4048/4885 |
| US-20180244603-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | EP300, HTT, KAT2A | KDR 4838/4885BRAF 3541/4885EGFR 4178/4885 |
| US-20170121276-A1 | HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF | EP300, KAT2A, HTT | KDR 4841/4885BRAF 3509/4885EGFR 4018/4885 |
| US-20200330410-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | HDAC6, HDAC9, HDAC5 | KDR 4817/4885BRAF 2396/4885EGFR 4094/4885 |
| US-10653648-B2 | Histone acetyltransferase activators and compositions and uses thereof | HDAC6, HDAC9, HDAC5 | KDR 4817/4885BRAF 2396/4885EGFR 4094/4885 |
| US-20230165813-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | HDAC6, HDAC9, HDAC5 | KDR 4817/4885BRAF 2396/4885EGFR 4094/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.