SCHEMBL9952083

SCHEMBL9952083

CCOc1cccc(OCCCN(C)C)c1C(=O)Nc1ccc(Cl)c(C(F)(F)F)c1

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
RXFP1 Q9HBX9 2/20 0.50
KDR P35968 5/20 0.49
LMNA P02545 4/20 0.48
MAPT P10636 3/20 0.48
GAA P10253 2/20 0.48
RAB9A P51151 1/20 0.48
KCNK3 O14649 1/20 0.48
KCNK9 Q9NPC2 1/20 0.48
GRM4 Q14833 1/20 0.47
ALDH1A1 P00352 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
RAF1 P04049 1/20 0.45
SLC6A3 Q01959 2/20 0.44
MEN1 O00255 1/20 0.44
HTT P42858 1/20 0.44
KMT2A Q03164 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
UTS2R Q9UKP6 1/20 0.43
RET P07949 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9951429 0.95 RXFP1 (0.49) RXFP1KDRLMNAMAPTGAA
SCHEMBL31376514 0.95 RXFP1 (0.49) RXFP1KDRLMNAMAPTGAA
SCHEMBL29677914 0.95 RXFP1 (0.49) RXFP1KDRLMNAMAPTGAA
SCHEMBL9952014 0.92 KDR (0.49) KDRLMNAMAPTGAARAB9A
SCHEMBL18804910 0.91 RXFP1 (0.50) RXFP1KDRLMNAMAPTGAA
SCHEMBL17154497 0.90 LMNA (0.52) KDRLMNAMAPTGAARAB9A
SCHEMBL22339738 0.90 LMNA (0.57) KDRLMNAMAPTGAARAB9A
SCHEMBL22339754 0.90 TRPV1 (0.46) RXFP1KDRLMNAMAPTGAA
SCHEMBL22339734 0.90 RXFP1 (0.49) RXFP1KDRLMNAMAPTGAA
SCHEMBL10067171 0.89 LMNA (0.53) KDRLMNAMAPTGAARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230165813-A1 HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 2023-06-01 US disclosed
US-20220127232-A1 HISTONE ACETYLTRANSFERASE MODULATORS AND COMPOSITIONS AND USES THEREOF APPIA PHARMACEUTICALS LLC 2022-04-28 US disclosed
US-20200330410-A1 HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 2020-10-22 US disclosed
EP-3323813-B1 HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF UNIV COLUMBIA (US) 2020-08-26 EP disclosed
EP-3323813-B1 HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF UNIV COLUMBIA (US) 2020-08-26 EP disclosed
WO-2020163731-A1 HISTONE ACETYLTRANSFERASE MODULATORS AND COMPOSITIONS AND USES THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2020-08-13 WO disclosed
US-10653648-B2 Histone acetyltransferase activators and compositions and uses thereof THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2020-05-19 US disclosed
US-20180244603-A1 HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR 2018-08-30 US disclosed
EP-3323813-A1 HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF The Trustees of Columbia University in the City of New York (US) 2018-05-23 EP disclosed
EP-3323813-A1 HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF The Trustees of Columbia University in the City of New York (US) 2018-05-23 EP disclosed
US-9969677-B2 Histone acetyltransferase modulators and uses thereof THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2018-05-15 US disclosed
EP-2654428-B1 HISTONE ACETYLTRANSFERASE MODULATORS AND USESE THEREOF UNIV COLUMBIA (US) 2018-02-14 EP disclosed
EP-2654428-B1 HISTONE ACETYLTRANSFERASE MODULATORS AND USESE THEREOF UNIV COLUMBIA (US) 2018-02-14 EP disclosed
US-20180021273-A1 HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 2018-01-25 US disclosed
WO-2018017858-A1 HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2018-01-25 WO disclosed
US-20170121276-A1 HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2017-05-04 US disclosed
US-20170121276-A1 HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2017-05-04 US disclosed
EP-2654428-A1 HISTONE ACETYLTRANSFERASE MODULATORS AND USESE THEREOF The Trustees of Columbia University in the City of New York (US) 2013-10-30 EP disclosed
WO-2012088420-A1 HISTONE ACETYLTRANSFERASE MODULATORS AND USESE THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2012-06-28 WO disclosed
WO-2012088420-A1 HISTONE ACETYLTRANSFERASE MODULATORS AND USESE THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2012-06-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180021273-A1 HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF HDAC6, HDAC9, HDAC5 RXFP1 4599/4885KDR 4817/4885LMNA 1963/4885
US-20220127232-A1 HISTONE ACETYLTRANSFERASE MODULATORS AND COMPOSITIONS AND USES THEREOF EP300, KAT2A, NAA40 RXFP1 4617/4885KDR 4837/4885LMNA 2999/4885
US-20180244603-A1 HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF EP300, HTT, KAT2A RXFP1 4588/4885KDR 4838/4885LMNA 3534/4885
US-20170121276-A1 HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF EP300, KAT2A, HTT RXFP1 4586/4885KDR 4841/4885LMNA 3493/4885
US-20200330410-A1 HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF HDAC6, HDAC9, HDAC5 RXFP1 4599/4885KDR 4817/4885LMNA 1963/4885
US-10653648-B2 Histone acetyltransferase activators and compositions and uses thereof HDAC6, HDAC9, HDAC5 RXFP1 4599/4885KDR 4817/4885LMNA 1963/4885
US-20230165813-A1 HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF HDAC6, HDAC9, HDAC5 RXFP1 4599/4885KDR 4817/4885LMNA 1963/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.