Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20185613 | 0.83 | ALDH1A1 (0.49) | KDM4EL3MBTL1KMT2AMEN1POLB | |
| SCHEMBL19459421 | 0.81 | SMN1; SMN2 (0.44) | KDM4EL3MBTL1KMT2AMEN1POLB | |
| SCHEMBL27690138 | 0.80 | LMNA (0.45) | KDM4EL3MBTL1KMT2APOLBGAA | |
| SCHEMBL10751843 | 0.79 | HSP90AA1 (0.63) | KDM4EL3MBTL1KMT2AMEN1POLB | |
| SCHEMBL27773932 | 0.79 | POLB (0.41) | KDM4EL3MBTL1KMT2AMEN1POLB | |
| SCHEMBL1622556 | 0.77 | KDM4E (0.58) | KDM4EL3MBTL1KMT2AMEN1POLB | |
| SCHEMBL11027691 | 0.77 | KDM4E (0.43) | KDM4EL3MBTL1KMT2AMEN1GAA | |
| SCHEMBL23012554 | 0.77 | SMN1; SMN2 (0.50) | KDM4EL3MBTL1KMT2APOLBGAA | |
| SCHEMBL28121427 | 0.76 | KDM4E (0.56) | KDM4EL3MBTL1KMT2AMEN1POLB | |
| SCHEMBL5178813 | 0.75 | SMN1; SMN2 (0.53) | KDM4EL3MBTL1KMT2APOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655356-A1 | FAAH INHIBITORS | Ironwood Pharmaceuticals, Inc. (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012088469-A1 | FAAH INHIBITORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2012-06-28 | — | — | WO | disclosed |