Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 6/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.35 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952952 | 0.91 | PDE4B (0.36) | PDE4BDPP4NR1H2EHMT2USP30 | |
| SCHEMBL15996135 | 0.91 | PDE4B (0.38) | PDE4BNR1H2EHMT2KDM4EMEN1 | |
| SCHEMBL9952338 | 0.90 | DPP4 (0.38) | PDE4BDPP4EHMT2USP30SUV39H2 | |
| SCHEMBL9953121 | 0.86 | TAAR1 (0.35) | ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL15995172 | 0.81 | PDE4B (0.37) | PDE4BNR1H2EHMT2SUV39H2KDM4E | |
| SCHEMBL9953060 | 0.81 | MAPT (0.42) | DPP4ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL9929019 | 0.81 | PDE4B (0.38) | PDE4BNR1H2EHMT2USP30KDM4E | |
| SCHEMBL15995150 | 0.80 | KAT5 (0.37) | PDE4BDPP4NR1H2EHMT2USP30 | |
| SCHEMBL9952310 | 0.80 | KAT5 (0.37) | PDE4BDPP4NR1H2EHMT2USP30 | |
| SCHEMBL9928736 | 0.80 | MC4R (0.36) | PDE4BDPP4EHMT2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |