Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | STS | P08842 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952952 | 0.90 | PDE4B (0.36) | KDM4EDPP4ALDH1A1EPHX2TP53 | |
| SCHEMBL9953742 | 0.87 | PIK3CD (0.35) | ALDH1A1 | |
| SCHEMBL14736307 | 0.82 | MAPT (0.45) | MAPTKDM4ETHRBALDH1A1HTT | |
| SCHEMBL9928833 | 0.81 | PIK3CD (0.43) | MAPTKDM4ETHRBDPP4ALDH1A1 | |
| SCHEMBL9952096 | 0.81 | PDE4B (0.36) | KDM4EDPP4ALDH1A1MEN1KMT2A | |
| SCHEMBL15995172 | 0.81 | PDE4B (0.37) | KDM4EEPHX2NPBWR1MCHR1MEN1 | |
| SCHEMBL14736911 | 0.80 | MAPT (0.46) | MAPTKDM4ETHRBALDH1A1HTT | |
| SCHEMBL14736678 | 0.80 | MAPT (0.43) | MAPTKDM4ETHRBALDH1A1HTT | |
| SCHEMBL9952338 | 0.79 | DPP4 (0.38) | DPP4 | |
| SCHEMBL9952761 | 0.78 | IMPDH2 (0.37) | KDM4EALDH1A1MEN1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |