Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 4/20 | 0.32 |
| ▸ | DRD3 | P35462 | 3/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952761 | 0.90 | IMPDH2 (0.37) | TAAR1CYP1A2HTR2AKDM4EALDH1A1 | |
| SCHEMBL15995215 | 0.89 | DRD2 (0.32) | CYP1A2DRD2DRD3CYP2D6MEN1 | |
| SCHEMBL9952908 | 0.89 | TAAR1 (0.34) | TAAR1CYP1A2HTR2AKDM4EALDH1A1 | |
| SCHEMBL9952096 | 0.86 | PDE4B (0.36) | KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL14742669 | 0.79 | IMPDH2 (0.37) | CYP1A2DRD2DRD3CYP2D6MEN1 | |
| SCHEMBL14742518 | 0.79 | IMPDH2 (0.37) | CYP1A2DRD2DRD3CYP2D6MEN1 | |
| SCHEMBL9953742 | 0.79 | PIK3CD (0.35) | TAAR1CYP1A2HTR2AALDH1A1DRD2 | |
| SCHEMBL14742435 | 0.78 | HSD17B10 (0.35) | CYP1A2KDM4EALDH1A1GAACYP2D6 | |
| SCHEMBL9952960 | 0.78 | DRD2 (0.31) | CYP1A2DRD2DRD3CYP2D6MEN1 | |
| SCHEMBL9952461 | 0.78 | DRD2 (0.31) | CYP1A2DRD2DRD3CYP2D6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |