Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | PSMD10 | O75832 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 2/20 | 0.35 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.35 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SNCA | P37840 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9951836 | 0.89 | GRM1 (0.38) | DHODHPSMD10AURKAAURKBS1PR1 | |
| SCHEMBL9952549 | 0.81 | MEN1 (0.51) | DHODHALDH1A1MAPK10POLB | |
| SCHEMBL9952464 | 0.76 | GRM1 (0.42) | DHODHPSMD10AURKAAURKBPOLB | |
| SCHEMBL10195459 | 0.72 | MEN1 (0.46) | DHODHS1PR1POLB | |
| SCHEMBL19126510 | 0.67 | PSMD10 (0.55) | DHODHPSMD10AURKAAURKBNPC1 | |
| SCHEMBL9952570 | 0.66 | GRM1 (0.40) | ALDH1A1RAB9AGAANPC1SMN1; SMN2 | |
| SCHEMBL4050879 | 0.65 | LOXL2 (0.63) | ALDH1A1GAANPC1SMN1; SMN2 | |
| SCHEMBL31227601 | 0.64 | PSMD10 (0.52) | DHODHPSMD10ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL2671464 | 0.64 | CA12 (0.45) | ALDH1A1GAASMN1; SMN2POLBL3MBTL1 | |
| SCHEMBL33494 | 0.63 | LOXL2 (0.66) | ALDH1A1GAANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655357-A1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | Merck Serono S.A. (CH) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012084704-A1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO S.A. (CH) | 2012-06-28 | — | — | WO | disclosed |