Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 9/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952348 | 0.91 | PIK3CD (0.34) | PIK3CDCYP1A2IMPDH2MEN1ALDH1A1 | |
| SCHEMBL9952344 | 0.85 | PIK3CD (0.36) | PIK3CDCYP1A2MEN1ALDH1A1POLB | |
| SCHEMBL18917317 | 0.82 | HIF1A (0.37) | PIK3CDIMPDH2MAPT | |
| SCHEMBL9929333 | 0.75 | PIK3CD (0.44) | PIK3CD | |
| SCHEMBL9929196 | 0.71 | PIK3CD (0.42) | PIK3CD | |
| SCHEMBL9952363 | 0.70 | IMPDH2 (0.38) | PIK3CDIMPDH2POLB | |
| SCHEMBL14742272 | 0.67 | PDE10A (0.37) | PIK3CDMEN1MAPTHPGDKMT2A | |
| SCHEMBL14742496 | 0.67 | PIK3CD (0.55) | PIK3CD | |
| SCHEMBL14742313 | 0.67 | PIK3CD (0.53) | PIK3CD | |
| SCHEMBL14742450 | 0.67 | PDE10A (0.39) | PIK3CDMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |