Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.33 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.32 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.32 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.32 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.32 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.32 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.32 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | POLQ | O75417 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953364 | 0.83 | TAAR1 (0.36) | MAOBPIK3CD | |
| SCHEMBL9928927 | 0.77 | PRKAB2 (0.39) | IMPDH2PIK3CDPRKAB2PRKAG1PRKAA2 | |
| SCHEMBL9928762 | 0.75 | PIK3CD (0.42) | PIK3CD | |
| SCHEMBL12813032 | 0.74 | PIK3CD (0.48) | IMPDH2PIK3CD | |
| SCHEMBL9952348 | 0.71 | PIK3CD (0.34) | IMPDH2PIK3CDPOLB | |
| SCHEMBL9952574 | 0.70 | PIK3CD (0.33) | IMPDH2PIK3CDPOLB | |
| SCHEMBL9953161 | 0.69 | IMPDH2 (0.47) | IMPDH2 | |
| SCHEMBL9952076 | 0.69 | IMPDH2 (0.47) | IMPDH2 | |
| SCHEMBL9952629 | 0.69 | IMPDH2 (0.47) | IMPDH2 | |
| SCHEMBL9953479 | 0.68 | TSHR (0.43) | IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |