Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952112 | 0.87 | PIK3CD (0.44) | PIK3CDPTGDR2 | |
| SCHEMBL9929160 | 0.82 | PIK3CD (0.44) | PIK3CDGPR55PIK3C3PTGDR2SCN5A | |
| SCHEMBL9929356 | 0.81 | PIK3CD (0.42) | PIK3CDGPR55PIK3C3SCN5ASCN9A | |
| SCHEMBL9953064 | 0.81 | PIK3CD (0.40) | PIK3CDPIK3C3 | |
| Hydrochloric Acid SCHEMBL9928961 | 0.81 | PIK3CD (0.42) | PIK3CDGPR55PIK3C3SCN5ASCN9A | |
| SCHEMBL19571043 | 0.80 | PIK3CD (0.39) | PIK3CDGPR55PIK3C3PTGDR2SCN5A | |
| SCHEMBL9928787 | 0.78 | PIK3C3 (0.38) | PIK3CDGPR55PIK3C3PTGDR2SCN9A | |
| SCHEMBL9929246 | 0.75 | LMNA (0.32) | CYP2C9 | |
| SCHEMBL9952024 | 0.73 | PIK3CD (0.37) | PIK3CDGPR55PIK3C3CYP2C9 | |
| Hydrochloric Acid SCHEMBL9953058 | 0.72 | PIK3CD (0.36) | PIK3CDGPR55PIK3C3CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |