Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 9/20 | 0.48 |
| ▸ | PDE4A | P27815 | 10/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9951939 | 0.86 | PIK3CD (0.47) | PIK3CDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9953256 | 0.83 | PIK3CD (0.45) | PIK3CDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9953002 | 0.80 | PIK3CD (0.50) | PIK3CDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9929221 | 0.78 | PIK3CD (0.60) | PIK3CDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9952961 | 0.77 | PIK3CD (0.45) | PIK3CDKCNH2 | |
| SCHEMBL17337252 | 0.77 | PIK3CD (0.52) | PIK3CDPDE4AKCNH2 | |
| SCHEMBL9952761 | 0.75 | IMPDH2 (0.37) | PIK3CDTAAR1 | |
| SCHEMBL9953258 | 0.74 | PIK3CD (0.54) | PIK3CDPDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL9952097 | 0.74 | PIK3CD (0.38) | PIK3CDTAAR1 | |
| SCHEMBL14742563 | 0.73 | IMPDH2 (0.33) | PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |