Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 8/20 | 0.50 |
| ▸ | PDE4A | P27815 | 11/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | VEGFA | P15692 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9951939 | 0.82 | PIK3CD (0.47) | PIK3CDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9953256 | 0.81 | PIK3CD (0.45) | PIK3CDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9952929 | 0.80 | PIK3CD (0.48) | PIK3CDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9929221 | 0.79 | PIK3CD (0.60) | PIK3CDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9953258 | 0.77 | PIK3CD (0.54) | PIK3CDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9929718 | 0.74 | PIK3CD (0.56) | PIK3CDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9928886 | 0.71 | PIK3CD (0.50) | PIK3CDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30276021 | 0.70 | PIK3CD (0.62) | PIK3CDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28952539 | 0.70 | PIK3CD (0.62) | PIK3CDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28952186 | 0.70 | PIK3CD (0.51) | PIK3CDPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |