Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953841 | 0.80 | LMNA (0.39) | LMNAHTTCYP1A2SMN1; SMN2 | |
| SCHEMBL9952884 | 0.79 | LMNA (0.33) | LMNAHTTCYP1A2 | |
| SCHEMBL9928712 | 0.75 | LMNA (0.34) | LMNAHTTCYP1A2GLA | |
| SCHEMBL20254981 | 0.72 | PDE2A (0.36) | LMNAHTTSMN1; SMN2 | |
| SCHEMBL29688185 | 0.72 | PDE2A (0.36) | LMNAHTTSMN1; SMN2 | |
| SCHEMBL3835882 | 0.71 | LMNA (0.37) | HTR2AHTR2CHTR2BLMNAHTT | |
| SCHEMBL18054720 | 0.71 | LMNA (0.32) | LMNAHTTCYP1A2 | |
| SCHEMBL9929183 | 0.71 | CYP3A4 (0.41) | LMNAHTTCYP1A2SMN1; SMN2 | |
| SCHEMBL17337252 | 0.70 | PIK3CD (0.52) | — | |
| SCHEMBL9952809 | 0.70 | TAAR1 (0.45) | HTR2AHTR2CHTR2BTAAR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |