Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | BPTF | Q12830 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953070 | 0.80 | HTR2A (0.39) | LMNAHTTSMN1; SMN2CYP1A2 | |
| SCHEMBL9952884 | 0.75 | LMNA (0.33) | LMNAHTTALDH1A1L3MBTL1CYP1A2 | |
| SCHEMBL9953839 | 0.74 | LMNA (0.39) | LMNAHTTBPTFTSHRALDH1A1 | |
| SCHEMBL9953766 | 0.73 | HTT (0.36) | LMNAHTTTSHRRENALDH1A1 | |
| SCHEMBL9929183 | 0.72 | CYP3A4 (0.41) | LMNAHTTBPTFTSHRALDH1A1 | |
| SCHEMBL28114021 | 0.71 | LMNA (0.38) | LMNAHTTBPTFTSHRALDH1A1 | |
| SCHEMBL20254981 | 0.68 | PDE2A (0.36) | LMNAHTTALDH1A1HPGDMEN1 | |
| SCHEMBL9928712 | 0.68 | LMNA (0.34) | LMNAHTTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL29688185 | 0.68 | PDE2A (0.36) | LMNAHTTALDH1A1HPGDMEN1 | |
| SCHEMBL17138433 | 0.67 | ALDH1A1 (0.36) | LMNAHTTALDH1A1L3MBTL1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |