Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9954686 | 0.99 | PIK3C3 (0.53) | PIK3C3HTTTP53CASP1SMN1; SMN2 | |
| SCHEMBL14305926 | 0.96 | PIK3C3 (0.55) | PIK3C3HTTTP53CASP1SMN1; SMN2 | |
| SCHEMBL9954020 | 0.93 | PIK3C3 (0.49) | PIK3C3HTTTP53CASP1SMN1; SMN2 | |
| Pyridine SCHEMBL9955114 | 0.92 | PIK3C3 (0.48) | PIK3C3HTTTP53CASP1SMN1; SMN2 | |
| SCHEMBL21760960 | 0.88 | PIK3C2G (0.48) | PIK3C3HTTSMN1; SMN2POLBKDM4E | |
| SCHEMBL19303684 | 0.88 | PIK3C2G (0.48) | PIK3C3HTTSMN1; SMN2POLBKDM4E | |
| SCHEMBL9953196 | 0.88 | PIK3CG (0.46) | PIK3C3HTTTP53CASP1SMN1; SMN2 | |
| SCHEMBL9953667 | 0.81 | PIK3C3 (0.42) | PIK3C3POLBKDM4EHSD17B10MAPT | |
| SCHEMBL14317987 | 0.80 | PI4KB (0.42) | PIK3C3SMN1; SMN2POLBALDH1A1MEN1 | |
| SCHEMBL23663187 | 0.79 | PIK3C3 (0.47) | PIK3C3HTTTP53CASP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012174312-A2 | BENZIMIDAZOLE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-12-20 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |