Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.41 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | BRD2 | P25440 | 1/20 | 0.41 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14305926 | 0.95 | PIK3C3 (0.55) | PIK3C3KDM4EHSD17B10L3MBTL1SMN1; SMN2 | |
| SCHEMBL9954686 | 0.95 | PIK3C3 (0.53) | PIK3C3KDM4EHSD17B10SMN1; SMN2HTT | |
| SCHEMBL19303684 | 0.94 | PIK3C2G (0.48) | PIK3C3KDM4EHSD17B10L3MBTL1SMN1; SMN2 | |
| SCHEMBL21760960 | 0.94 | PIK3C2G (0.48) | PIK3C3KDM4EHSD17B10L3MBTL1SMN1; SMN2 | |
| SCHEMBL9953075 | 0.93 | PIK3C3 (0.52) | PIK3C3KDM4EHSD17B10SMN1; SMN2HTT | |
| SCHEMBL9953196 | 0.91 | PIK3CG (0.46) | PIK3C3KDM4EHSD17B10L3MBTL1SMN1; SMN2 | |
| Pyridine SCHEMBL9955114 | 0.86 | PIK3C3 (0.48) | PIK3C3KDM4EHSD17B10SMN1; SMN2HTT | |
| SCHEMBL9953667 | 0.85 | PIK3C3 (0.42) | PIK3C3KDM4EHSD17B10L3MBTL1POLB | |
| SCHEMBL9953641 | 0.81 | SHMT2 (0.44) | L3MBTL1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL23585301 | 0.80 | L3MBTL1 (0.53) | PIK3C3L3MBTL1SMN1; SMN2HTTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012174312-A2 | BENZIMIDAZOLE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-12-20 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |