Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 5/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9952097 | 0.84 | PIK3CD (0.38) | PIK3CD | |
| Hydrochloric Acid SCHEMBL9929198 | 0.78 | PIK3CD (0.46) | PIK3CD | |
| SCHEMBL9952477 | 0.77 | PDE4A (0.41) | PIK3CD | |
| SCHEMBL9952122 | 0.74 | PIK3CD (0.37) | PIK3CD | |
| SCHEMBL29836162 | 0.74 | PIK3CD (0.47) | PIK3CD | |
| SCHEMBL9951939 | 0.73 | PIK3CD (0.47) | PIK3CD | |
| SCHEMBL9928935 | 0.73 | PIK3CD (0.45) | PIK3CD | |
| SCHEMBL18265674 | 0.72 | PIK3CD (0.43) | PIK3CD | |
| SCHEMBL9952491 | 0.71 | PIK3CD (0.36) | PIK3CD | |
| SCHEMBL9929110 | 0.69 | PIK3CD (0.38) | PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |