Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 14/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952618 | 0.82 | P2RX7 (0.37) | PDE4APDE4BPDE4CPDE4DBRD4 | |
| Trifluoroacetic Acid SCHEMBL9954210 | 0.79 | PDE4A (0.34) | PDE4APDE4BPDE4CPDE4DBRD4 | |
| SCHEMBL9951939 | 0.78 | PIK3CD (0.47) | PDE4APDE4BPDE4CPDE4DPIK3CD | |
| SCHEMBL9953097 | 0.77 | PIK3CD (0.37) | PIK3CD | |
| SCHEMBL9929243 | 0.74 | PIK3CD (0.41) | PDE4APDE4BPDE4CPDE4DBRD4 | |
| SCHEMBL9952257 | 0.73 | PIK3CD (0.33) | PIK3CD | |
| SCHEMBL9952122 | 0.72 | PIK3CD (0.37) | PIK3CD | |
| Trifluoroacetic Acid SCHEMBL9929098 | 0.71 | PIK3CD (0.37) | PDE4APDE4BPDE4CPDE4DBRD4 | |
| SCHEMBL20240848 | 0.65 | IMPDH2 (0.37) | — | |
| SCHEMBL11658969 | 0.65 | BRD4 (0.57) | PDE4APDE4BPDE4CPDE4DBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |