Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 19/20 | 0.57 |
| ▸ | JAK2 | O60674 | 11/20 | 0.57 |
| ▸ | JAK3 | P52333 | 8/20 | 0.50 |
| ▸ | TYK2 | P29597 | 5/20 | 0.50 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.48 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | PRKCA | P17252 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953293 | 0.89 | JAK1 (0.56) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL2294782 | 0.86 | JAK1 (0.67) | JAK1JAK2JAK3TYK2AURKA | |
| SCHEMBL2294790 | 0.86 | JAK1 (0.67) | JAK1JAK2JAK3TYK2AURKA | |
| SCHEMBL10281993 | 0.84 | JAK1 (0.58) | JAK1JAK2JAK3TYK2MAP3K19 | |
| SCHEMBL27432005 | 0.83 | JAK2 (0.61) | JAK1JAK2JAK3TYK2AURKA | |
| SCHEMBL9953450 | 0.81 | JAK2 (0.75) | JAK1JAK2JAK3TYK2MAP3K19 | |
| SCHEMBL27433394 | 0.81 | JAK1 (0.60) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL25240987 | 0.80 | JAK1 (0.66) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL25289131 | 0.80 | JAK1 (0.66) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL29460632 | 0.80 | JAK1 (0.66) | JAK1JAK2JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085176-A1 | TRICYCLIC PYRAZINONE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF AS JANUS KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012085176-A1 | TRICYCLIC PYRAZINONE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF AS JANUS KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-06-28 | — | — | WO | disclosed |