Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | GSK3B | P49841 | 3/20 | 0.49 |
| ▸ | ATR | Q13535 | 3/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 7/20 | 0.47 |
| ▸ | PIM1 | P11309 | 5/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 5/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18284528 | 0.82 | PIM1 (0.48) | MAPTGSK3BPIM1PIM3PIM2 | |
| SCHEMBL9911853 | 0.81 | MAPT (0.46) | MAPTGSK3BATRKDM4CPIM1 | |
| SCHEMBL16515562 | 0.80 | PIM1 (0.45) | MAPTGSK3BKDM4CPIM1PIM3 | |
| SCHEMBL1711507 | 0.79 | PIM2 (0.58) | GSK3BPIM1PIM3PIM2 | |
| SCHEMBL15770659 | 0.79 | ATR (0.58) | MAPTGSK3BATRKDM4CPIM1 | |
| SCHEMBL9953027 | 0.78 | GPR119 (0.43) | MAPTGSK3BATRKDM4C | |
| SCHEMBL2695221 | 0.78 | PIM2 (0.43) | GSK3BPIM1PIM3PIM2 | |
| SCHEMBL13737663 | 0.77 | MAPT (0.42) | MAPTGSK3BATRKDM4CPIM1 | |
| SCHEMBL15818020 | 0.75 | AOC1 (0.46) | MAPTGSK3BATRKDM4CIDO1 | |
| SCHEMBL30053721 | 0.75 | KDM4C (0.48) | MAPTKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106986862-A | Hepatitis c inhibitor and application thereof | ABBVIE 公司 | 2017-07-28 | — | — | CN | disclosed |
| CN-103649079-B | Hepatitis c inhibitor and application thereof | ABBVIE 公司 | 2016-11-16 | — | — | CN | disclosed |
| EP-2655362-A1 | HEPATITIS C INHIBITORS AND USES THEREOF | Abbvie Inc. (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087833-A1 | HEPATITIS C INHIBITORS AND USES THEREOF | ABBOTT LABORATORIES (US) | 2012-06-28 | — | — | WO | disclosed |